EUB0000005b_NTRK1

Chemical structure of compound EUB0000005b
Compound name
DDR-TRK-1 (D2202-1)
Protein family
Protein Kinase
Target name
NTRK1
Affinity biochemical (nM)
43
Affinity on-target cellular (nM)
448
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000005b
SMILES
Cc1cn(-c2cc(NC(=O)c3ccc4c(c3)CN(c3cncnc3)C[C@@H]4C)cc(C(F)(F)F)c2)cn1
InChIKey
CMJJZRAAQMUAFH-INIZCTEOSA-N
NCBI gene ID
4914
UniProt ID
P04629
Synonyms
TRK, TRKA, MTC
Mode of action
Inhibitor
Negative control
DDR-TRK-1N (380079)
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic inhibition assay
Affinity Biochemical Source Knowledge
https://www.thesgc.org/chemical-probes/DDR-TRK-1
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET assay (HEK293T cells)
Affinity on-target cellular relation
=
Selectivity platform
ScanMAX (DiscoverX)
Selectivity platform number of targets
468
Selectivity remarks
Screened at 1 µM, in vitro activity of closest targets: Kd(CDK11) = 370 nM, Kd(EPHA8) = 550 nM, Kd(MUSK) = 530 nM
Selectivity Source Knowledge
https://www.thesgc.org/chemical-probes/DDR-TRK-1
Selectivity Number of Off-targets
3