Publications | EUbOPEN

2023

Pérez Berrocal DA, Vishwanatha TM, Horn-Ghetko D, Botsch JJ, Hehl LA, Kostrhon S, Misra M, Ðikić I, Geurink PP, van Dam H, Schulman BA, Mulder MPC. (2023) A Pro-Fluorescent Ubiquitin-Based Probe to Monitor Cysteine-Based E3 Ligase Activity. Angew Chem Int Ed Engl. 62(32):e202303319. doi:10.1002/anie.202303319

Grätz L, Kowalski-Jahn M, Scharf MM, Kozielewicz P, Jahn M, Bous J, Lambert NA, Gloriam DE, Schulte G. (2023) Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations. Nat Commun. 14(1):4573. Published 2023 Jul 29. doi:10.1038/s41467-023-40213-0

Lauschke VM, Zhou Y, Ingelman-Sundberg M. (2023) Pharmacogenomics Beyond Single Common Genetic Variants: The Way Forward [published online ahead of print, 2023 Jul 28]. Annu Rev Pharmacol Toxicol. 10.1146/annurev-pharmtox-051921-091209. doi:10.1146/annurev-pharmtox-051921-091209

Farin HF, Mosa MH, Ndreshkjana B, Grebbin BM, Ritter B, Menche C, Kennel KB, Ziegler PK, Szabo L, Bollrath J, Rieder D, Michels BE, Kress A, Bozlar M, Darvishi T, Stier S, Kur IM, Bankov K, Kesselring R, Fichtner-Feigl S, Brune B, Goetze TO, Al-Batran SE, Brandts CH, Bechstein WO, Wild PJ, Weigert A, Muller S, Knapp S, Trajanoski Z, Greten FR. (2023) Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses. [published online ahead of print, 2023 Jul 25]. Cancer Discov. 2023;CD-23-0050. doi:10.1158/2159-8290.CD-23-0050

Barreby E, Strunz B, Nock S, Naudet L, Shen JX, Johansson H, Sönnerborg I, Ma J, Urgard E, Pallett LJ, Hu Y, Fardellas A, Azzimato V, Vankova A, Levi L, Morgantini C, Maini MK, Stål P, Rosshart SP, Coquet JM, Nowak G, Näslund E, Lauschke VM, Ellis E, Björkström NK, Chen P, Aouadi M. (2023) Human resident liver myeloid cells protect against metabolic stress in obesity. Nat Metab. 5(7):1188-1203. doi:10.1038/s42255-023-00834-7

Balıkçı E, Marques AMC, Hansen JS, Huber KVM. Open resources for chemical probes and their implications for future drug discovery. Expert Opin Drug Discov. 2023;18(5):505-513. doi:10.1080/17460441.2023.2199979

Tredup C, Ndreshkjana B, Schneider NS, Tjaden A, Kemas AM, Youhanna S, Lauschke VM, Berger BT, Krämer A, Berger LM, Röhm S, Knapp S, Farin HF, Müller S. (2023) Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum. ACS Chem Biol. 18(4):822-836. doi:10.1021/acschembio.2c00877

Li ASM, Kimani S, Wilson B, Noureldin M, González-Álvarez H, Mamai A, Hoffer L, Guilinger JP, Zhang Y, von Rechenberg M, Disch JS, Mulhern CJ, Slakman BL, Cuozzo JW, Dong A, Poda G, Mohammed M, Saraon P, Mittal M, Modh P, Rathod V, Patel B, Ackloo S, Santhakumar V, Szewczyk MM, Barsyte-Lovejoy D, Arrowsmith CH, Marcellus R, Guié MA, Keefe AD, Brown PJ, Halabelian L, Al-Awar R, Vedadi M. (2023) Discovery of Nanomolar DCAF1 Small Molecule Ligands. J Med Chem. 66(7):5041-5060. doi:10.1021/acs.jmedchem.2c02132

Uliana F, Ciuffa R, Mishra R, Fossati A, Frommelt F, Keller S, Mehnert M, Birkeland ES, van Drogen F, Srejic N, Peter M, Tapon N, Aebersold R, Gstaiger M. (2023) Phosphorylation-linked complex profiling identifies assemblies required for Hippo signal integration. Mol Syst Biol. 2023;19(4):e11024. doi:10.15252/msb.202211024

Mons E, Kim RQ, Mulder MPC. (2023) Technologies for Direct Detection of Covalent Protein-Drug Adducts. Pharmaceuticals (Basel). 16(4):547. Published 2023 Apr 5. doi:10.3390/ph16040547

Li F, Ghiabi P, Hajian T, Klima M, Li ASM, Khalili Yazdi A, Chau I, Loppnau P, Kutera M, Seitova A, Bolotokova A, Hutchinson A, Perveen S, Boura E, Vedadi M. (2023) SS148 and WZ16 inhibit the activities of nsp10-nsp16 complexes from all seven human pathogenic coronaviruses. Biochim Biophys Acta Gen Subj. 1867(4):130319. doi:10.1016/j.bbagen.2023.130319

Haubrich K, Spiteri VA, Farnaby W, Sobott F, Ciulli A. (2023) Breaking free from the crystal lattice: Structural biology in solution to study protein degraders. Curr Opin Struct Biol. 79:102534. doi:10.1016/j.sbi.2023.102534

Wright SC, Lauschke VM. (2023) Rewiring of catecholamine-induced calcium signalling is an early event in non-alcoholic fatty liver disease. J Physiol. 601(8):1317-1318. doi:10.1113/JP284526

Ackloo S, Antolin AA, Bartolome JM, Beck H, Bullock A, Betz UAK, Böttcher J, Brown PJ, Chaturvedi M, Crisp A, Daniels D, Dreher J, Edfeldt K, Edwards AM, Egner U, Elkins J, Fischer C, Glendorf T, Goldberg S, Hartung IV, Hillisch A, Homan E, Knapp S, Köster M, Krämer O, Llaveria J, Lessel U, Lindemann S, Linderoth L, Matsui H, Michel M, Montel F, Mueller-Fahrnow A, Müller S, Owen DR, Saikatendu KS, Santhakumar V, Sanderson W, Scholten C, Schapira M, Sharma S, Shireman B, Sundström M, Todd MH, Tredup C, Venable J, Willson TM, Arrowsmith CH. (2023) Target 2035 - an update on private sector contributions. RSC Med Chem. 14(6):1002-1011. Published 2023 Mar 16. doi:10.1039/d2md00441k

Martinelli P, Schaaf O, Mantoulidis A, Martin LJ, Fuchs JE, Bader G, Gollner A, Wolkerstorfer B, Rogers C, Balıkçı E, Lipp JJ, Mischerikow N, Doebel S, Gerstberger T, Sommergruber W, Huber KVM, Böttcher J. (2023) Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments. ChemMedChem. 18(6):e202200686. doi:10.1002/cmdc.202200686

Göricke F, Vu V, Smith L, Scheib U, Böhm R, Akkilic N, Wohlfahrt G, Weiske J, Bömer U, Brzezinka K, Lindner N, Lienau P, Gradl S, Beck H, Brown PJ, Santhakumar V, Vedadi M, Barsyte-Lovejoy D, Arrowsmith CH, Schmees N, Petersen K. (2023) Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. J Med Chem. 66(5):3431-3447. doi:10.1021/acs.jmedchem.2c01933

Němec V, Khirsariya P, Janovská P, Moyano PM, Maier L, Procházková P, Kebková P, Gybel' T, Berger BT, Chaikuad A, Reinecke M, Kuster B, Knapp S, Bryja V, Paruch K. (2023) Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity. Angew Chem Int Ed Engl. 62(11):e202217532. doi:10.1002/anie.202217532

Ong HW, Truong A, Kwarcinski F, de Silva C, Avalani K, Havener TM, Chirgwin M, Galal KA, Willis C, Krämer A, Liu S, Knapp S, Derbyshire ER, Zutshi R, Drewry DH.(2023) Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore. Eur J Med Chem. 249:115043. doi:10.1016/j.ejmech.2022.115043

Aakula A, Sharma M, Tabaro F, Nätkin R, Kamila J, Honkanen H, Schapira M, Arrowsmith C, Nykter M, Westermarck J. (2023) RAS and PP2A activities converge on epigenetic gene regulation. Life Sci Alliance. 6(5):e202301928. Published 2023 Mar 1. doi:10.26508/lsa.202301928

MacDonald KM, Nicholson-Puthenveedu S, Tageldein MM, Khasnis S, Arrowsmith CH, Harding SM. (2023) Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei. Nat Commun. 14(1):556. Published 2023 Feb 2. doi:10.1038/s41467-023-36195-8

Denis HL, Alpaugh M, Alvarez CP, Fenyi A, Barker RA, Chouinard S, Arrowsmith CH, Melki R, Labib R, Harding RJ, Cicchetti F. (2023) Detection of antibodies against the huntingtin protein in human plasma. Cell Mol Life Sci. 80(2):45. Published 2023 Jan 18. doi:10.1007/s00018-023-04687-x

Zhou J, Horton JR, Menna M, Fiorentino F, Ren R, Yu D, Hajian T, Vedadi M, Mazzoccanti G, Ciogli A, Weinhold E, Hüben M, Blumenthal RM, Zhang X, Mai A, Rotili D, Cheng X. (2023) Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence. J Med Chem. 66(1):934-950. doi:10.1021/acs.jmedchem.2c01789

Antolin, A. A., Sanfelice, D., Crisp, A., Villasclaras Fernandez, E., Mica, I. L., Chen, Y., Collins, I., Edwards, A., Müller, S., Al-Lazikani, B., & Workman, P. (2023). The Chemical Probes Portal: an expert review-based public resource to empower chemical probe assessment, selection and use. Nucleic acids research, 51(D1), D1492–D1502. https://doi.org/10.1093/nar/gkac909

Taebnia N, Römling U, Lauschke VM. (2023) In vitro and ex vivo modeling of enteric bacterial infections. Gut Microbes. 15(1):2158034. doi:10.1080/19490976.2022.2158034

2022

Tjaden, A., Giessmann, R. T., Knapp, S., Schröder, M., & Müller, S. (2022). High-content live-cell multiplex screen for chemogenomic compound annotation based on nuclear morphology. STAR protocols, 3(4), 101791. https://doi.org/10.1016/j.xpro.2022.101791

Zandi Shafagh R, Youhanna S, Keulen J, Shen JX, Taebnia N, Preiss LC, Klein K, Büttner FA, Bergqvist M, van der Wijngaart W, Lauschke VM. (2022) Bioengineered Pancreas-Liver Crosstalk in a Microfluidic Coculture Chip Identifies Human Metabolic Response Signatures in Prediabetic Hyperglycemia. Adv Sci (Weinh). 9(34):e2203368. doi:10.1002/advs.202203368

Zhou Y, Lauschke VM. (2022) The genetic landscape of major drug metabolizing cytochrome P450 genes-an updated analysis of population-scale sequencing data. Pharmacogenomics J. 22(5-6):284-293. doi:10.1038/s41397-022-00288-2

Amrhein JA, Berger LM, Tjaden A, Krämer A, Elson L, Tolvanen T, Martinez-Molina D, Kaiser A, Schubert-Zsilavecz M, Müller S, Knapp S, Hanke T. (2022) Discovery of 3-Amino-1H-pyrazole-Based Kinase Inhibitors to Illuminate the Understudied PCTAIRE Family. Int J Mol Sci. 23(23):14834. Published 2022 Nov 27. doi:10.3390/ijms232314834

Rovers E, Liu L, Schapira M. ProxyBind: A compendium of binding sites for proximity-induced pharmacology. Comput Struct Biotechnol J. 2022;20:6163-6171. Published 2022 Nov 8. doi:10.1016/j.csbj.2022.11.010

Chaikuad, A., Zhubi, R., Tredup, C., & Knapp, S. (2022). Comparative structural analyses of the NHL domains from the human E3 ligase TRIM-NHL family. IUCrJ, 9(Pt 6), 720–727. https://doi.org/10.1107/S2052252522008582

Voorneveld, J., Kloet, M. S., Wijngaarden, S., Kim, R. Q., Moutsiopoulou, A., Verdegaal, M., Misra, M., Đikić, I., van der Marel, G. A., Overkleeft, H. S., Filippov, D. V., & van der Heden van Noort, G. J. (2022). Arginine ADP-Ribosylation: Chemical Synthesis of Post-Translationally Modified Ubiquitin Proteins. Journal of the American Chemical Society, 144(45), 20582–20589. https://doi.org/10.1021/jacs.2c06249

Payliss BJ, Tse YWE, Reichheld SE, Lemak A, Yun HY, Houliston S, Patel A, Arrowsmith CH, Sharpe S, Wyatt HDM. (2022) Phosphorylation of the DNA repair scaffold SLX4 drives folding of the SAP domain and activation of the MUS81-EME1 endonuclease. Cell Rep. 41(4):111537. doi:10.1016/j.celrep.2022.111537

Ketley RF, Battistini F, Alagia A, Mondielli C, Iehl F, Balikçi E, Huber KVM, Orozco M, Gullerova M. (2022) DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation. Cell Rep. 41(4):111526. doi:10.1016/j.celrep.2022.111526

Pentinmikko N, Lozano R, Scharaw S, Andersson S, Englund JI, Castillo-Azofeifa D, Gallagher A, Broberg M, Song KY, Sola Carvajal A, Speidel AT, Sundstrom M, Allbritton N, Stevens MM, Klein OD, Teixeira A, Katajisto P. (2022) Cellular shape reinforces niche to stem cell signaling in the small intestine. Sci Adv. 2022;8(41):eabm1847. doi:10.1126/sciadv.abm1847

Hanke, T., Mathea, S., Woortman, J., Salah, E., Berger, B. T., Tumber, A., Kashima, R., Hata, A., Kuster, B., Müller, S., & Knapp, S. (2022). Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes. Journal of medicinal chemistry, 65(19), 13264–13287. https://doi.org/10.1021/acs.jmedchem.2c01106

Jia Y, Kim RQ, Kooij R, Ovaa H, Sapmaz A, Geurink PP. (2022) Chemical Toolkit for PARK7: Potent, Selective, and High-Throughput. J Med Chem. 65(19):13288-13304. doi:10.1021/acs.jmedchem.2c01113

Kim TE, Tsuboyama K, Houliston S, Martell CM, Phoumyvong CM, Lemak A, Haddox HK, Arrowsmith CH, Rocklin GJ. (2022) Dissecting the stability determinants of a challenging de novo protein fold using massively parallel design and experimentation. Proc Natl Acad Sci U S A. 119(41):e2122676119. doi:10.1073/pnas.2122676119

Lesbon, J. C. C., Garnica, T. K., Xavier, P. L. P., Rochetti, A. L., Reis, R. M., Müller, S., & Fukumasu, H. (2022). A Screening of Epigenetic Therapeutic Targets for Non-Small Cell Lung Cancer Reveals PADI4 and KDM6B as Promising Candidates. International journal of molecular sciences, 23(19), 11911. https://doi.org/10.3390/ijms231911911

Ciuffa R, Uliana F, Mannion J, Mehnert M, Tenev T, Marulli C, Satanowski A, Keller LML, Rodilla Ramírez PN, Ori A, Gstaiger M, Meier P, Aebersold R. (2022) Novel biochemical, structural, and systems insights into inflammatory signaling revealed by contextual interaction proteomics. Proc Natl Acad Sci U S A. 119(40):e2117175119. doi:10.1073/pnas.2117175119

Chidyausiku TM, Mendes SR, Klima JC, Nadal M, Eckhard U, Roel-Touris J, Houliston S, Guevara T, Haddox HK, Moyer A, Arrowsmith CH, Gomis-Rüth FX, Baker D, Marcos E. (2022) De novo design of immunoglobulin-like domains. Nat Commun. 13(1):5661. Published 2022 Oct 3. doi:10.1038/s41467-022-33004-6

Liu L, Rovers E, Schapira M. (2022) ChemBioPort: an online portal to navigate the structure, function and chemical inhibition of the human proteome. Database (Oxford). 2022:baac088. doi:10.1093/database/baac088

Wallner O, Cázares-Körner A, Scaletti ER, Masuyer G, Bekkhus T, Visnes T, Mamonov K, Ortis F, Lundbäck T, Volkova M, Koolmeister T, Wiita E, Loseva O, Pandey M, Homan E, Benítez-Buelga C, Davies J, Scobie M, Warpman Berglund U, Kalderén C, Stenmark P, Helleday T, Michel M. (2023) Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1. ChemMedChem. 18(1):e202200310. doi:10.1002/cmdc.202200310

Liu Y, Iqbal A, Li W, Ni Z, Wang Y, Ramprasad J, Abraham KJ, Zhang M, Zhao DY, Qin S, Loppnau P, Jiang H, Guo X, Brown PJ, Zhen X, Xu G, Mekhail K, Ji X, Bedford MT, Greenblatt JF, Min J. (2022) A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun. 13(1):5453. Published 2022 Sep 16. doi:10.1038/s41467-022-33229-5

Fraser BJ, Beldar S, Seitova A, Hutchinson A, Mannar D, Li Y, Kwon D, Tan R, Wilson RP, Leopold K, Subramaniam S, Halabelian L, Arrowsmith CH, Bénard F. (2022) Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation. Nat Chem Biol. 18(9):963-971. doi:10.1038/s41589-022-01059-7

Liu, X., Kalogeropulou, A. F., Domingos, S., Makukhin, N., Nirujogi, R. S., Singh, F., Shpiro, N., Saalfrank, A., Sammler, E., Ganley, I. G., Moreira, R., Alessi, D. R., & Ciulli, A. (2022). Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2. Journal of the American Chemical Society, 144(37), 16930–16952. https://doi.org/10.1021/jacs.2c05499

Wu Q, Nie DY, Ba-Alawi W, Ji Y, Zhang Z, Cruickshank J, Haight J, Ciamponi FE, Chen J, Duan S, Shen Y, Liu J, Marhon SA, Mehdipour P, Szewczyk MM, Dogan-Artun N, Chen W, Zhang LX, Deblois G, Prinos P, Massirer KB, Barsyte-Lovejoy D, Jin J, De Carvalho DD, Haibe-Kains B, Wang X, Cescon DW, Lupien M, Arrowsmith CH. (2022) PRMT inhibition induces a viral mimicry response in triple-negative breast cancer. Nat Chem Biol. 18(8):821-830. doi:10.1038/s41589-022-01024-4

Trush, V. V., Feller, C., Li, A. S. M., Allali-Hassani, A., Szewczyk, M. M., Chau, I., Eram, M. S., Jiang, B., Luu, R., Zhang, F., Barsyte-Lovejoy, D., Aebersold, R., Arrowsmith, C. H., & Vedadi, M. (2022). Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro. Biochimica et biophysica acta. Gene regulatory mechanisms, 1865(5), 194845. https://doi.org/10.1016/j.bbagrm.2022.194845

Tsika, A. C., Gallo, A., Fourkiotis, N. K., Argyriou, A. I., Sreeramulu, S., Löhr, F., Rogov, V. V., Richter, C., Linhard, V., Gande, S. L., Altincekic, N., Krishnathas, R., Elamri, I., Schwalbe, H., Wollenhaupt, J., Weiss, M. S., & Spyroulias, G. A. (2022). Binding Adaptation of GS-441524 Diversifies Macro Domains and Downregulates SARS-CoV-2 de-MARylation Capacity. Journal of molecular biology, 434(16), 167720. https://doi.org/10.1016/j.jmb.2022.167720

Jemth AS, Scaletti ER, Homan E, Stenmark P, Helleday T, Michel M. (2022) Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir. J Biol Chem. 298(8):102169. doi:10.1016/j.jbc.2022.102169

Tolvanen TA. (2022) Current Advances in CETSA. Front Mol Biosci. 9:866764. Published 2022 Jun 9. doi:10.3389/fmolb.2022.866764

Zhou, Y., & Lauschke, V. M. (2022). Population pharmacogenomics: an update on ethnogeographic differences and opportunities for precision public health. Human genetics, 141(6), 1113–1136. https://doi.org/10.1007/s00439-021-02385-x

Schwalm, M. P., Berger, L. M., Meuter, M. N., Vasta, J. D., Corona, C. R., Röhm, S., Berger, B. T., Farges, F., Beinert, S. M., Preuss, F., Morasch, V., Rogov, V. V., Mathea, S., Saxena, K., Robers, M. B., Müller, S., & Knapp, S. (2022). A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins. Frontiers in cell and developmental biology, 10, 886537. https://doi.org/10.3389/fcell.2022.886537

Cruz Walma, D. A., Chen, Z., Bullock, A. N., & Yamada, K. M. (2022). Ubiquitin ligases: guardians of mammalian development. Nature reviews. Molecular cell biology, 23(5), 350–367. https://doi.org/10.1038/s41580-021-00448-5

Stork, B. A., Dean, A., Ortiz, A. R., Saha, P., Putluri, N., Planas-Silva, M. D., Mahmud, I., Rajapakshe, K., Coarfa, C., Knapp, S., Lorenzi, P. L., Kemp, B. E., Turk, B. E., Scott, J. W., Means, A. R., & York, B. (2022). Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism. Molecular metabolism, 62, 101513. https://doi.org/10.1016/j.molmet.2022.101513

Willems, S., Marschner, J. A., Kilu, W., Faudone, G., Busch, R., Duensing-Kropp, S., Heering, J., & Merk, D. (2022). Nurr1 Modulation Mediates Neuroprotective Effects of Statins. Advanced science (Weinheim, Baden-Wurttemberg, Germany), e2104640. Advance online publication. https://doi.org/10.1002/advs.202104640

Willems, S., Müller, M., Ohrndorf, J., Heering, J., Proschak, E., & Merk, D. (2022). Scaffold Hopping from Amodiaquine to Novel Nurr1 Agonist Chemotypes via Microscale Analogue Libraries. ChemMedChem, 17(8), e202200026. https://doi.org/10.1002/cmdc.202200026

Borsari, C., Keles, E., McPhail, J. A., Schaefer, A., Sriramaratnam, R., Goch, W., Schaefer, T., De Pascale, M., Bal, W., Gstaiger, M., Burke, J. E., & Wymann, M. P. (2022). Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα. Journal of the American Chemical Society, 144(14), 6326–6342. https://doi.org/10.1021/jacs.1c13568

Isigkeit, L., Chaikuad, A., & Merk, D. (2022). A Consensus Compound/Bioactivity Dataset for Data-Driven Drug Design and Chemogenomics. Molecules (Basel, Switzerland), 27(8), 2513. https://doi.org/10.3390/molecules27082513

Sun, Z. W., Waybright, J. M., Beldar, S., Chen, L., Foley, C. A., Norris-Drouin, J. L., Lyu, T. J., Dong, A., Min, J., Wang, Y. P., James, L. I., & Wang, Y. (2022). Cdyl Deficiency Brakes Neuronal Excitability and Nociception through Promoting Kcnb1 Transcription in Peripheral Sensory Neurons. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 9(10), e2104317. https://doi.org/10.1002/advs.202104317

Wei, Y., Redel, C., Ahlner, A., Lemak, A., Johansson-Åkhe, I., Houliston, S., Kenney, T., Tamachi, A., Morad, V., Duan, S., Andrews, D. W., Wallner, B., Sunnerhagen, M., Arrowsmith, C. H., & Penn, L. Z. (2022). The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase. Nucleic acids research, 50(6), 3505–3522. https://doi.org/10.1093/nar/gkac138

Chen, Z., Ioris, R. M., Richardson, S., Van Ess, A. N., Vendrell, I., Kessler, B. M., Buffa, F. M., Busino, L., Clifford, S. C., Bullock, A. N., & D'Angiolella, V. (2022). Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation. Cell death and differentiation, 10.1038/s41418-022-00983-4. Advance online publication. https://doi.org/10.1038/s41418-022-00983-4

Srour, N., Villarreal, O. D., Hardikar, S., Yu, Z., Preston, S., Miller, W. H., Jr, Szewczyk, M. M., Barsyte-Lovejoy, D., Xu, H., Chen, T., Del Rincón, S. V., & Richard, S. (2022). PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade. Cell reports, 38(13), 110582. https://doi.org/10.1016/j.celrep.2022.110582

Szewczyk, M. M., Luciani, G. M., Vu, V., Murison, A., Dilworth, D., Barghout, S. H., Lupien, M., Arrowsmith, C. H., Minden, M. D., & Barsyte-Lovejoy, D. (2022). PRMT5 regulates ATF4 transcript splicing and oxidative stress response. Redox biology, 51, 102282. https://doi.org/10.1016/j.redox.2022.102282

Edwards, A. M., Baric, R. S., Saphire, E. O., & Ulmer, J. B. (2022). Stopping pandemics before they start: Lessons learned from SARS-CoV-2. Science (New York, N.Y.), 375(6585), 1133–1139. https://doi.org/10.1126/science.abn1900

Notarnicola, A., Preger, C., Lundström, S. L., Renard, N., Wigren, E., Van Gompel, E., Galindo-Feria, A. S., Persson, H., Fathi, M., Grunewald, J., Jakobsson, P. J., Gräslund, S., Lundberg, I. E., & Fernandes-Cerqueira, C. (2022). Longitudinal assessment of reactivity and affinity profile of anti-Jo1 autoantibodies to distinct HisRS domains and a splice variant in a cohort of patients with myositis and anti-synthetase syndrome. Arthritis research & therapy, 24(1), 62. https://doi.org/10.1186/s13075-022-02745-6

Rocha, C., & Prinos, P. (2022). Post-transcriptional and Post-translational Modifications of Primary Cilia: How to Fine Tune Your Neuronal Antenna. Frontiers in cellular neuroscience, 16, 809917. https://doi.org/10.3389/fncel.2022.809917

Weng, J. H., Aoto, P. C., Lorenz, R., Wu, J., Schmidt, S. H., Manschwetus, J. T., Kaila-Sharma, P., Silletti, S., Mathea, S., Chatterjee, D., Knapp, S., Herberg, F. W., & Taylor, S. S. (2022). LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains. PLoS biology, 20(2), e3001427. https://doi.org/10.1371/journal.pbio.3001427

Tjaden, A., Chaikuad, A., Kowarz, E., Marschalek, R., Knapp, S., Schröder, M., & Müller, S. (2022). Image-Based Annotation of Chemogenomic Libraries for Phenotypic Screening. Molecules (Basel, Switzerland), 27(4), 1439. https://doi.org/10.3390/molecules27041439

Dilworth, D., Hanley, R. P., Ferreira de Freitas, R., Allali-Hassani, A., Zhou, M., Mehta, N., Marunde, M. R., Ackloo, S., Carvalho Machado, R. A., Khalili Yazdi, A., Owens, D., Vu, V., Nie, D. Y., Alqazzaz, M., Marcon, E., Li, F., Chau, I., Bolotokova, A., Qin, S., Lei, M., … Schapira, M. (2022). A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nature chemical biology, 18(1), 56–63. https://doi.org/10.1038/s41589-021-00898-0

Galindo-Feria, A. S., Horuluoglu, B., Day, J., Fernandes-Cerqueira, C., Wigren, E., Gräslund, S., Proudman, S., Lundberg, I. E., & Limaye, V. (2022). Autoantibodies against Four-and-a-Half-LIM Domain 1 (FHL1) in Inflammatory Myopathies: Results from an Australian Single-Center Cohort. Rheumatology (Oxford, England), keac003. Advance online publication. https://doi.org/10.1093/rheumatology/keac003

Peng, X., Baxa, M., Faruk, N., Sachleben, J. R., Pintscher, S., Gagnon, I. A., Houliston, S., Arrowsmith, C. H., Freed, K. F., Rocklin, G. J., & Sosnick, T. R. (2022). Prediction and Validation of a Protein's Free Energy Surface Using Hydrogen Exchange and (Importantly) Its Denaturant Dependence. Journal of chemical theory and computation, 18(1), 550–561. https://doi.org/10.1021/acs.jctc.1c00960

Baltzer, S., Bulatov, T., Schmied, C., Krämer, A., Berger, B. T., Oder, A., Walker-Gray, R., Kuschke, C., Zühlke, K., Eichhorst, J., Lehmann, M., Knapp, S., Weston, J., von Kries, J. P., Süssmuth, R. D., & Klussmann, E. (2022). Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells. International journal of molecular sciences, 23(2), 763. https://doi.org/10.3390/ijms23020763

Erdogdu, U., Dolgikh, N., Laszig, S., Särchen, V., Meister, M. T., Wanior, M., Knapp, S., & Boedicker, C. (2022). Selective BH3 mimetics synergize with BET inhibition to induce mitochondrial apoptosis in rhabdomyosarcoma cells. Neoplasia (New York, N.Y.), 24(2), 109–119. https://doi.org/10.1016/j.neo.2021.11.012

Chen, Z., Zhang, J., Murillo-de-Ozores, A. R., Castañeda-Bueno, M., D'Amico, F., Heilig, R., Manning, C. E., Sorrell, F. J., D'Angiolella, V., Fischer, R., Mulder, M., Gamba, G., Alessi, D. R., & Bullock, A. N. (2022). Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase. The Biochemical journal, 479(5), 661–675. https://doi.org/10.1042/BCJ20220019

2021

Delaney, K., Tan, M., Zhu, Z., Gao, J., Dai, L., Kim, S., Ding, J., He, M., Halabelian, L., Yang, L., Nagarajan, P., Parthun, M. R., Lee, S., Khochbin, S., Zheng, Y. G., & Zhao, Y. (2021). Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2. Cell discovery, 7(1), 122. https://doi.org/10.1038/s41421-021-00344-4

Klein, V. G., Bond, A. G., Craigon, C., Lokey, R. S., & Ciulli, A. (2021). Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity. Journal of medicinal chemistry, 64(24), 18082–18101. https://doi.org/10.1021/acs.jmedchem.1c01496

Harding, R. J., Deme, J. C., Hevler, J. F., Tamara, S., Lemak, A., Cantle, J. P., Szewczyk, M. M., Begeja, N., Goss, S., Zuo, X., Loppnau, P., Seitova, A., Hutchinson, A., Fan, L., Truant, R., Schapira, M., Carroll, J. B., Heck, A., Lea, S. M., & Arrowsmith, C. H. (2021). Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1. Communications biology, 4(1), 1374. https://doi.org/10.1038/s42003-021-02895-4

Müller, S., Ackloo, S., Al Chawaf, A., Al-Lazikani, B., Antolin, A., Baell, J. B., Beck, H., Beedie, S., Betz, U., Bezerra, G. A., Brennan, P. E., Brown, D., Brown, P. J., Bullock, A. N., Carter, A. J., Chaikuad, A., Chaineau, M., Ciulli, A., Collins, I., Dreher, J., … Arrowsmith, C. H. (2021). Target 2035 - update on the quest for a probe for every protein. RSC medicinal chemistry, 13(1), 13–21. https://doi.org/10.1039/d1md00228g

Azzimato, V., Chen, P., Barreby, E., Morgantini, C., Levi, L., Vankova, A., Jager, J., Sulen, A., Diotallevi, M., Shen, J. X., Miller, A., Ellis, E., Rydén, M., Näslund, E., Thorell, A., Lauschke, V. M., Channon, K. M., Crabtree, M. J., Haschemi, A., Craige, S. M., … Aouadi, M. (2021). Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity. Gastroenterology, 161(6), 1982–1997.e11. https://doi.org/10.1053/j.gastro.2021.08.030

Chen, S., Zhou, M., Dong, A., Loppnau, P., Wang, M., Min, J., & Liu, K. (2021). Structural basis of the TAM domain of BAZ2A in binding to DNA or RNA independent of methylation status. The Journal of biological chemistry, 297(6), 101351. https://doi.org/10.1016/j.jbc.2021.101351

Laveglia, V., Giachetti, A., Cerofolini, L., Haubrich, K., Fragai, M., Ciulli, A., & Rosato, A. (2021). Automated Determination of Nuclear Magnetic Resonance Chemical Shift Perturbations in Ligand Screening Experiments: The PICASSO Web Server. Journal of chemical information and modeling, 61(12), 5726–5733. https://doi.org/10.1021/acs.jcim.1c00871

Imaide, S., Riching, K. M., Makukhin, N., Vetma, V., Whitworth, C., Hughes, S. J., Trainor, N., Mahan, S. D., Murphy, N., Cowan, A. D., Chan, K. H., Craigon, C., Testa, A., Maniaci, C., Urh, M., Daniels, D. L., & Ciulli, A. (2021). Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity. Nature chemical biology, 17(11), 1157–1167. https://doi.org/10.1038/s41589-021-00878-4

Yu, D., Horton, J. R., Yang, J., Hajian, T., Vedadi, M., Sagum, C. A., Bedford, M. T., Blumenthal, R. M., Zhang, X., & Cheng, X. (2021). Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions. Nucleic acids research, 49(20), 11629–11642. https://doi.org/10.1093/nar/gkab460

Guegueniat, J., Halabelian, L., Zeng, H., Dong, A., Li, Y., Wu, H., Arrowsmith, C. H., & Kothe, U. (2021). The human pseudouridine synthase PUS7 recognizes RNA with an extended multi-domain binding surface. Nucleic acids research, 49(20), 11810–11822. https://doi.org/10.1093/nar/gkab934

Lyczek, A., Berger, B. T., Rangwala, A. M., Paung, Y., Tom, J., Philipose, H., Guo, J., Albanese, S. K., Robers, M. B., Knapp, S., Chodera, J. D., & Seeliger, M. A. (2021). Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance. Proceedings of the National Academy of Sciences of the United States of America, 118(46), e2111451118. https://doi.org/10.1073/pnas.2111451118

Dilworth, D., Hanley, R. P., Ferreira de Freitas, R., Allali-Hassani, A., Zhou, M., Mehta, N., Marunde, M. R., Ackloo, S., Carvalho Machado, R. A., Khalili Yazdi, A., Owens, D., Vu, V., Nie, D. Y., Alqazzaz, M., Marcon, E., Li, F., Chau, I., Bolotokova, A., Qin, S., Lei, M., … Schapira, M. (2022). A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nature chemical biology, 18(1), 56–63. https://doi.org/10.1038/s41589-021-00898-0

Koromina, M., Pandi, M. T., van der Spek, P. J., Patrinos, G. P., & Lauschke, V. M. (2021). The ethnogeographic variability of genetic factors underlying G6PD deficiency. Pharmacological research, 173, 105904. https://doi.org/10.1016/j.phrs.2021.105904

Attwood, M. M., Fabbro, D., Sokolov, A. V., Knapp, S., & Schiöth, H. B. (2021). Trends in kinase drug discovery: targets, indications and inhibitor design. Nature reviews. Drug discovery, 20(11), 839–861. https://doi.org/10.1038/s41573-021-00252-y

Chen, S., Zhou, M., Dong, A., Loppnau, P., Wang, M., Min, J., & Liu, K. (2021). Structural basis of the TAM domain of BAZ2A in binding to DNA or RNA independent of methylation status. The Journal of biological chemistry, 297(6), 101351. https://doi.org/10.1016/j.jbc.2021.101351

Imaide, S., Riching, K. M., Makukhin, N., Vetma, V., Whitworth, C., Hughes, S. J., Trainor, N., Mahan, S. D., Murphy, N., Cowan, A. D., Chan, K. H., Craigon, C., Testa, A., Maniaci, C., Urh, M., Daniels, D. L., & Ciulli, A. (2021). Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity. Nature chemical biology, 17(11), 1157–1167. https://doi.org/10.1038/s41589-021-00878-4

Guo, Y., Liu, Q., Mallette, E., Caba, C., Hou, F., Fux, J., LaPlante, G., Dong, A., Zhang, Q., Zheng, H., Tong, Y., & Zhang, W. (2021). Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1. The Journal of biological chemistry, 297(4), 101107. https://doi.org/10.1016/j.jbc.2021.101107

Röhm, S., Berger, B. T., Schröder, M., Chatterjee, D., Mathea, S., Joerger, A. C., Pinkas, D. M., Bufton, J. C., Tjaden, A., Kovooru, L., Kudolo, M., Pohl, C., Bullock, A. N., Müller, S., Laufer, S., & Knapp, S. (2021). Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe. Journal of medicinal chemistry, 64(18), 13451–13474. https://doi.org/10.1021/acs.jmedchem.1c00868

Robers, M. B., Wilkinson, J. M., Vasta, J. D., Berger, L. M., Berger, B. T., & Knapp, S. (2021). Single tracer-based protocol for broad-spectrum kinase profiling in live cells with NanoBRET. STAR protocols, 2(4), 100822. https://doi.org/10.1016/j.xpro.2021.100822

Zhou, Y., Arribas, G. H., Turku, A., Jürgenson, T., Mkrtchian, S., Krebs, K., Wang, Y., Svobodova, B., Milani, L., Schulte, G., Korabecny, J., Gastaldello, S., & Lauschke, V. M. (2021). Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine. Science advances, 7(36), eabi6856. https://doi.org/10.1126/sciadv.abi6856

Ali, M., McAuley, M. M., Lüchow, S., Knapp, S., Joerger, A. C., & Ivarsson, Y. (2021). Integrated analysis of Shank1 PDZ interactions with C-terminal and internal binding motifs. Current research in structural biology, 3, 41–50. https://doi.org/10.1016/j.crstbi.2021.01.001

Otava, T., Šála, M., Li, F., Fanfrlík, J., Devkota, K., Perveen, S., Chau, I., Pakarian, P., Hobza, P., Vedadi, M., Boura, E., & Nencka, R. (2021). The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors. ACS infectious diseases, 7(8), 2214–2220. https://doi.org/10.1021/acsinfecdis.1c00131

Henderson, S. H., Sorrell, F., Bennett, J., Fedorov, O., Hanley, M. T., Godoi, P. H., Ruela de Sousa, R., Robinson, S., Ashall-Kelly, A., Hopkins Navratilova, I., Walter, D. S., Elkins, J. M., & Ward, S. E. (2021). Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors. Journal of medicinal chemistry, 64(15), 11709–11728. https://doi.org/10.1021/acs.jmedchem.1c01115

Schröder, M., & Chaikuad, A. (2021). Assessing reversible and irreversible binding effects of kinase covalent inhibitors through ADP-Glo assays. STAR protocols, 2(3), 100717. https://doi.org/10.1016/j.xpro.2021.100717

Reggio, A., Buonomo, V., Berkane, R., Bhaskara, R. M., Tellechea, M., Peluso, I., Polishchuk, E., Di Lorenzo, G., Cirillo, C., Esposito, M., Hussain, A., Huebner, A. K., Hübner, C. A., Settembre, C., Hummer, G., Grumati, P., & Stolz, A. (2021). Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy, and Collagen quality control. EMBO reports, e52289. Advance online publication. https://doi.org/10.15252/embr.202052289

Drewry, D. H., Annor-Gyamfi, J. K., Wells, C. I., Pickett, J. E., Dederer, V., Preuss, F., Mathea, S., & Axtman, A. D. (2022). Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration. Journal of medicinal chemistry, 65(2), 1313–1328. https://doi.org/10.1021/acs.jmedchem.1c00440

Youhanna, S., Wright, S. C., & Lauschke, V. M. (2021). Organotypic human ex vivo models for coronavirus disease 2019 research and drug development. Current opinion in pharmacology, 59, 11–18. https://doi.org/10.1016/j.coph.2021.04.006

Edwards, A., & Hartung, I. V. (2021). No shortcuts to SARS-CoV-2 antivirals. Science (New York, N.Y.), 373(6554), 488–489. https://doi.org/10.1126/science.abj9488

Halabelian, L., & Barsyte-Lovejoy, D. (2021). Structure and Function of Protein Arginine Methyltransferase PRMT7. Life (Basel, Switzerland), 11(8), 768. https://doi.org/10.3390/life11080768

Stebbing, J., & Lauschke, V. M. (2021). JAK Inhibitors - More Than Just Glucocorticoids. The New England journal of medicine, 385(5), 463–465. https://doi.org/10.1056/NEJMe2108667

Raab, M., Rak, M., Tesch, R., Gasimli, K., Becker, S., Knapp, S., Strebhardt, K., & Sanhaji, M. (2021). The Small-Molecule Inhibitor MRIA9 Reveals Novel Insights into the Cell Cycle Roles of SIK2 in Ovarian Cancer Cells. Cancers, 13(15), 3658. https://doi.org/10.3390/cancers13153658

Nonga, O. E., Lavogina, D., Enkvist, E., Kestav, K., Chaikuad, A., Dixon-Clarke, S. E., Bullock, A. N., Kopanchuk, S., Ivan, T., Ekambaram, R., Viht, K., Knapp, S., & Uri, A. (2021). Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family. Molecules (Basel, Switzerland), 26(14), 4353. https://doi.org/10.3390/molecules26144353

Wesch, N., Löhr, F., Rogova, N., Dötsch, V., & Rogov, V. V. (2021). A Concerted Action of UBA5 C-Terminal Unstructured Regions Is Important for Transfer of Activated UFM1 to UFC1. International journal of molecular sciences, 22(14), 7390. https://doi.org/10.3390/ijms22147390

Shen, J. X., Couchet, M., Dufau, J., de Castro Barbosa, T., Ulbrich, M. H., Helmstädter, M., Kemas, A. M., Zandi Shafagh, R., Marques, M. A., Hansen, J. B., Mejhert, N., Langin, D., Rydén, M., & Lauschke, V. M. (2021). 3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8(16), e2100106. https://doi.org/10.1002/advs.202100106

Pernaute-Lau, L., Adegnika, A. A., Zhou, Y., Zinsou, J. F., Gil, J. P., Krishna, S., Kremsner, P. G., Lauschke, V. M., & Velavan, T. P. (2021). Pharmacogene Sequencing of a Gabonese Population with Severe Plasmodium falciparum Malaria Reveals Multiple Novel Variants with Putative Relevance for Antimalarial Treatment. Antimicrobial agents and chemotherapy, 65(7), e0027521. https://doi.org/10.1128/AAC.00275-21

Schmidt, S. H., Weng, J. H., Aoto, P. C., Boassa, D., Mathea, S., Silletti, S., Hu, J., Wallbott, M., Komives, E. A., Knapp, S., Herberg, F. W., & Taylor, S. S. (2021). Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2. Proceedings of the National Academy of Sciences of the United States of America, 118(23), e2100844118. https://doi.org/10.1073/pnas.2100844118

Wallner, O., Mamonov, K., Ortis, F., Michel, D., Michel, M. (2021). Assembly and Application of a Low Budget Photoreactor. Chemistry – Methods 1(5), 240-244. https://doi.org/10.1002/cmtd.202100022

Zhou, Y., & Lauschke, V. M. (2021). Computational Tools to Assess the Functional Consequences of Rare and Noncoding Pharmacogenetic Variability. Clinical pharmacology and therapeutics, 10.1002/cpt.2289. Advance online publication. https://doi.org/10.1002/cpt.2289

Russell, L. E., Zhou, Y., Almousa, A. A., Sodhi, J. K., Nwabufo, C. K., & Lauschke, V. M. (2021). Pharmacogenomics in the era of next generation sequencing - from byte to bedside. Drug metabolism reviews, 53(2), 253–278. https://doi.org/10.1080/03602532.2021.1909613

Dölle, A., Adhikari, B., Krämer, A., Weckesser, J., Berner, N., Berger, L. M., Diebold, M., Szewczyk, M. M., Barsyte-Lovejoy, D., Arrowsmith, C. H., Gebel, J., Löhr, F., Dötsch, V., Eilers, M., Heinzlmeir, S., Kuster, B., Sotriffer, C., Wolf, E., & Knapp, S. (2021). Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders. Journal of medicinal chemistry, 64(15), 10682–10710. https://doi.org/10.1021/acs.jmedchem.1c00146

Gama-Brambila, R. A., Chen, J., Dabiri, Y., Tascher, G., Němec, V., Münch, C., Song, G., Knapp, S., & Cheng, X. (2021). A Chemical Toolbox for Labeling and Degrading Engineered Cas Proteins. JACS Au, 1(6), 777–785. https://doi.org/10.1021/jacsau.1c00007

Wanior, M., Krämer, A., Knapp, S., & Joerger, A. C. (2021). Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy. Oncogene, 40(21), 3637–3654. https://doi.org/10.1038/s41388-021-01781-x

Yadav, J., El Hassani, M., Sodhi, J., Lauschke, V. M., Hartman, J. H., & Russell, L. E. (2021). Recent developments in in vitro and in vivo models for improved translation of preclinical pharmacokinetics and pharmacodynamics data. Drug metabolism reviews, 53(2), 207–233. https://doi.org/10.1080/03602532.2021.1922435

Ma, T., Hu, C., Lal, B., Zhou, W., Ma, Y., Ying, M., Prinos, P., Quiñones-Hinojosa, A., Lim, M., Laterra, J., & Li, Y. (2021). Reprogramming Transcription Factors Oct4 and Sox2 Induce a BRD-Dependent Immunosuppressive Transcriptome in GBM-Propagating Cells. Cancer research, 81(9), 2457–2469. https://doi.org/10.1158/0008-5472.CAN-20-2489

Ingelman-Sundberg, M., & Lauschke, V. M. (2021). 3D human liver spheroids for translational pharmacology and toxicology. Basic & clinical pharmacology & toxicology, 10.1111/bcpt.13587. Advance online publication. https://doi.org/10.1111/bcpt.13587

Luparello, C., Cruciata, I., Joerger, A. C., Ocasio, C. A., Jones, R., Tareque, R. K., Bagley, M. C., Spencer, J., Walker, M., Austin, C., Ferrara, T., D Oca, P., Bellina, R., Branni, R., & Caradonna, F. (2021). Genotoxicity and Epigenotoxicity of Carbazole-Derived Molecules on MCF-7 Breast Cancer Cells. International journal of molecular sciences, 22(7), 3410. https://doi.org/10.3390/ijms22073410

Ni, X., Londregan, A. T., Owen, D. R., Knapp, S., & Chaikuad, A. (2021). Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants. ACS chemical biology, 16(4), 571–578. https://doi.org/10.1021/acschembio.0c00960

Karatas, M., Chaikuad, A., Berger, B., Kubbutat, M., Totzke, F., Knapp, S., & Kunick, C. (2021). 7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones Designed by a "Cut and Glue" Strategy Are Dual Aurora A/VEGF-R Kinase Inhibitors. Molecules (Basel, Switzerland), 26(6), 1611. https://doi.org/10.3390/molecules26061611

Lauschke V. M. (2021). Toxicogenomics of drug induced liver injury - from mechanistic understanding to early prediction. Drug metabolism reviews, 53(2), 245–252. https://doi.org/10.1080/03602532.2021.1894571

Kemas, A. M., Youhanna, S., Zandi Shafagh, R., & Lauschke, V. M. (2021). Insulin-dependent glucose consumption dynamics in 3D primary human liver cultures measured by a sensitive and specific glucose sensor with nanoliter input volume. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(3), e21305. https://doi.org/10.1096/fj.202001989RR

Santhakumar, V., Sutherland, M., Li, A., Kaghad, A., Panagopoulos, D., Li, F., Szewczyk, M., Smil, D., Scholten, C., Bouché, L., Stellfeld, T., Arrowsmith, C. H., Barsyte, D., Vedadi, M., Hartung, I. V., Steuber, H., & Britton, R. (2021). Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics. ChemMedChem, 10.1002/cmdc.202100018. Advance online publication. https://doi.org/10.1002/cmdc.202100018

Williams, E., Riesebos, E., Kerr, G., & Bullock, A. N. (2021). ALK2 Receptor Kinase Association with FKBP12.6 Is Structurally Conserved with the ALK2-FKBP12 Complex. Biomedicines, 9(2), 129. https://doi.org/10.3390/biomedicines9020129

Berger, B. T., Amaral, M., Kokh, D. B., Nunes-Alves, A., Musil, D., Heinrich, T., Schröder, M., Neil, R., Wang, J., Navratilova, I., Bomke, J., Elkins, J. M., Müller, S., Frech, M., Wade, R. C., & Knapp, S. (2021). Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2. Cell chemical biology, S2451-9456(21)00003-9. Advance online publication. https://doi.org/10.1016/j.chembiol.2021.01.003

Lemos, C., Schulze, V. K., Baumgart, S. J., Nevedomskaya, E., Heinrich, T., Lefranc, J., Bader, B., Christ, C. D., Briem, H., Kuhnke, L. P., Holton, S. J., Bömer, U., Lienau, P., von Nussbaum, F., Nising, C. F., Bauser, M., Hägebarth, A., Mumberg, D., & Haendler, B. (2021). The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models. Cellular oncology (Dordrecht), 10.1007/s13402-020-00584-8. Advance online publication. https://doi.org/10.1007/s13402-020-00584-8

D'Amico, F., Mukhopadhyay, R., Ovaa, H., & Mulder, M. (2021). Targeting TRIM Proteins: A quest towards drugging an emerging protein class. Chembiochem : a European journal of chemical biology, 10.1002/cbic.202000787. Advance online publication. https://doi.org/10.1002/cbic.202000787

Desta, Z., El-Boraie, A., Gong, L., Somogyi, A. A., Lauschke, V. M., Dandara, C., Klein, K., Miller, N. A., Klein, T. E., Tyndale, R. F., Whirl-Carrillo, M., & Gaedigk, A. (2021). PharmVar GeneFocus: CYP2B6. Clinical pharmacology and therapeutics, 110(1), 82–97. https://doi.org/10.1002/cpt.2166

Wells, C. I., Al-Ali, H., Andrews, D. M., Asquith, C., Axtman, A. D., Dikic, I., Ebner, D., Ettmayer, P., Fischer, C., Frederiksen, M., Futrell, R. E., Gray, N. S., Hatch, S. B., Knapp, S., Lücking, U., Michaelides, M., Mills, C. E., Müller, S., Owen, D., Picado, A., … Drewry, D. H. (2021). The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification. International journal of molecular sciences, 22(2), 566. https://doi.org/10.3390/ijms22020566

Stebbing, J., Sánchez Nievas, G., Falcone, M., Youhanna, S., Richardson, P., Ottaviani, S., Shen, J. X., Sommerauer, C., Tiseo, G., Ghiadoni, L., Virdis, A., Monzani, F., Rizos, L. R., Forfori, F., Avendaño Céspedes, A., De Marco, S., Carrozzi, L., Lena, F., Sánchez-Jurado, P. M., Lacerenza, L. G., … Lauschke, V. M. (2021). JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality. Science advances, 7(1), eabe4724. https://doi.org/10.1126/sciadv.abe4724

2020

Forster, M., Liang, X. J., Schröder, M., Gerstenecker, S., Chaikuad, A., Knapp, S., Laufer, S., & Gehringer, M. (2020). Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK. International journal of molecular sciences, 21(23), 9269. https://doi.org/10.3390/ijms21239269

Ramachandran, S., & Ciulli, A. (2020). Building ubiquitination machineries: E3 ligase multi-subunit assembly and substrate targeting by PROTACs and molecular glues. Current opinion in structural biology, 67, 110–119. Advance online publication. https://doi.org/10.1016/j.sbi.2020.10.009

Preuss, F., Chatterjee, D., Mathea, S., Shrestha, S., St-Germain, J., Saha, M., Kannan, N., Raught, B., Rottapel, R., & Knapp, S. (2020). Nucleotide Binding, Evolutionary Insights, and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4. Structure (London, England : 1993), 28(11), 1184–1196.e6. https://doi.org/10.1016/j.str.2020.07.016

Ishida, T., & Ciulli, A. (2020). E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones. SLAS discovery : advancing life sciences R & D, 2472555220965528. Advance online publication. https://doi.org/10.1177/2472555220965528

Youhanna, S., & Lauschke, V. M. (2021). The Past, Present and Future of Intestinal In Vitro Cell Systems for Drug Absorption Studies. Journal of pharmaceutical sciences, 110(1), 50–65. https://doi.org/10.1016/j.xphs.2020.07.001

Meijer, I., Willems, S., Ni, X., Heering, J., Chaikuad, A., & Merk, D. (2020). Chemical Starting Matter for HNF4α Ligand Discovery and Chemogenomics. International journal of molecular sciences, 21(21), 7895. https://doi.org/10.3390/ijms21217895

Zhou, Y., Dagli Hernandez, C., & Lauschke, V. M. (2020). Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier. British journal of cancer, 123(12), 1782–1789. https://doi.org/10.1038/s41416-020-01084-0

Schröder, M., Bullock, A. N., Fedorov, O., Bracher, F., Chaikuad, A., & Knapp, S. (2020). DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity. Journal of medicinal chemistry, 63(18), 10224–10234. https://doi.org/10.1021/acs.jmedchem.0c00898

Wu, Q., Ba-Alawi, W., Deblois, G., Cruickshank, J., Duan, S., Lima-Fernandes, E., Haight, J., Tonekaboni, S., Fortier, A. M., Kuasne, H., McKee, T. D., Mahmoud, H., Kushida, M., Cameron, S., Dogan-Artun, N., Chen, W., Nie, Y., Zhang, L. X., Vellanki, R. N., Zhou, S., … Arrowsmith, C. H. (2020). GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer. Nature communications, 11(1), 4205. https://doi.org/10.1038/s41467-020-18020-8