Compound name
YM-201636
Protein family
lipid-kinase
Target name
PIKFYVE
Affinity biochemical (nM)
33
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000014b
SMILES
O=C(C1=CC=C(N)N=C1)NC2=CC(C3=NC4=C(OC5=C4C=CC=N5)C(N6CCOCC6)=N3)=CC=C2
InChIKey
YBPIBGNBHHGLEB-UHFFFAOYSA-N
NCBI gene ID
200576
UniProt ID
Q9Y2I7
Synonyms
CFD, FAB1, HEL37, PIP5K, PIP5K3, ZFYVE29
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Radiometric assay (50 µM ATP)
Affinity Biochemical Source Knowledge
https://doi.org/10.1038/sj.embor.7401155
Affinity biochemical relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
448
Selectivity remarks
Screened at 1 µM, closest target as % of contr. PIK3CB (9.8%); Selective over PI3P, PI4P, PI34P, PI45P at 800 nM (radiolabel incorporation assay in NIH3T3 cells)
Selectivity Source Knowledge
https://doi.org/10.1038/sj.embor.7401155
Selectivity Number of Off-targets
1