Compound name
SRPKIN-1
Protein family
Protein Kinase
Target name
SRPK3
Affinity biochemical (nM)
4.81
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000023b
SMILES
O=S(C1=CC=CC(C2=C(CC)C=C3C(C(C)(C)C(NC4=C5C=CC(C#N)=C4)=C5C3=O)=C2)=C1)(F)=O
InChIKey
TWKWEBMGDALHPN-UHFFFAOYSA-N
NCBI gene ID
26576
UniProt ID
Q9UPE1
Synonyms
MSSK1
Mode of action
Covalent inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Biochemical activity assay (Reaction Biology)
Affinity Biochemical Source Knowledge
https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.2c01705
Affinity biochemical relation
=
Selectivity platform
Ambit KINOMEscan
Selectivity platform number of targets
402
Selectivity remarks
In vitro selectivity, screened at 1 µM, targets >90% of Ctrl. RET, LTK, PYK2,FLT3, ALK; KiNativ Technology screen against 265 kinases at 5 µM, Hela cells, highly selective after washout
Selectivity Source Knowledge
https://www.sciencedirect.com/science/article/pii/S2451945618300357?via%3Dihub
Selectivity Number of Off-targets
5