Compound name
Vactosertib
Protein family
Protein Kinase
Target name
ACVR1B
Affinity biochemical (nM)
17.2
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000041b
SMILES
Cc1cccc(-c2[nH]c(CNc3ccccc3F)nc2-c2ccc3ncnn3c2)n1
InChIKey
FJCDSQATIJKQKA-UHFFFAOYSA-N
NCBI gene ID
91
UniProt ID
P36896
Synonyms
ALK4, SKR2, ActRIB
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Radiometric protein kinase assay (33PanQinase Activity Assay)
Affinity Biochemical Source Knowledge
https://aacrjournals.org/mct/article/13/7/1704/91906/EW-7197-a-Novel-ALK-5-Kinase-Inhibitor-Potently
Affinity biochemical relation
=
Selectivity platform
Kinase panel (radiometric 33ProQinase Activity Assays, singlicates, ProQinase)
Selectivity platform number of targets
320
Selectivity remarks
Screened at 1 µM, closest targets as % residual activity: RIPK2 (7%), VEGFR2 (11%), MINK1 (21%), VEGFR3 (28%), VEGFR1 (38%), MAP4K4 (41%), PDGFRA(V561D) (43%), PDGFRA (47%), TGFBR2 (47%); In-vitro follow-up of closest targets (radioisotopic protein kinase assay, 33PanQinase activity assay): IC50(RIPK2) = 54 nM, IC50(VEGFR2) = 97 nM (https://pubs.acs.org/doi/10.1021/jm500115w); Selectivity within ALK family (Radioisotopic protein kinase assay, HotSpot assay, Reaction Biology): IC50(ALK1) >10 µM, IC50(ALK2) >10 µM, IC50(ALK3) >10 µM, IC50(ALK4) = 0.013 µM, IC50(ALK5) = 0.011 µM, IC50(ALK6) >10 µM, IC50(ALK7) n.d. (https://pubs.acs.org/doi/10.1021/jm500115w);
Selectivity Source Knowledge
https://aacrjournals.org/mct/article/13/7/1704/91906/EW-7197-a-Novel-ALK-5-Kinase-Inhibitor-Potently