EUB0000045b_BMX

Chemical structure of compound EUB0000045b
Compound name
BMX-IN-1
Protein family
Protein Kinase
Target name
BMX
Affinity biochemical (nM)
8
Affinity on-target cellular (nM)
138
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000045b
SMILES
CC1=C(C=C(C=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CC=C(C=C5)NS(=O)(=O)C)NC(=O)C=C
InChIKey
SFMJNHNUOVADRW-UHFFFAOYSA-N
NCBI gene ID
660
UniProt ID
P51813
Synonyms
ETK, PSCTK3
Mode of action
Covalent inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
SelectScreen Z’lyte assay (Invitrogen)
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/23594111/
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
BMX IP kinase assay in HEK293 cells
Affinity on-target cellular source knowledge
https://pubmed.ncbi.nlm.nih.gov/23594111/
Affinity on-target cellular relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
442
Selectivity remarks
Screened at 1 µM, S(10) = 0.01, closest targets as % of contr.: JAK3 (6.6%), PIP3CG (2.8%), PIP5K2C (5.6%), SBK1 (4.6%);
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/23594111/