Compound name
BMX-IN-1
Protein family
Protein Kinase
Target name
BTK
Affinity biochemical (nM)
10.4
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000045b
SMILES
CC1=C(C=C(C=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CC=C(C=C5)NS(=O)(=O)C)NC(=O)C=C
InChIKey
SFMJNHNUOVADRW-UHFFFAOYSA-N
NCBI gene ID
695
UniProt ID
Q06187
Synonyms
ATK, XLA, PSCTK1
Mode of action
Covalent inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
SelectScreen Z’lyte assay (Invitrogen)
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/23594111/
Affinity biochemical relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
442
Selectivity remarks
Screened at 1 µM, S(10) = 0.01, closest targets as % of contr.: JAK3 (6.6%), PIP3CG (2.8%), PIP5K2C (5.6%), SBK1 (4.6%);
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/23594111/