Compound name
Pictilisib (GDC-0941)
Protein family
Protein Kinase
Target name
PIK3CA
Affinity biochemical (nM)
0.76
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000049b
SMILES
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1
InChIKey
LHNIIDJUOCFXAP-UHFFFAOYSA-N
NCBI gene ID
5290
UniProt ID
P42336
Synonyms
PI3K
Mode of action
Inhibitor
Affinity biochemical definition
Kd
Affinity biochemical assay type
ScanMax technology (DiscoverX)
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/acs.jmedchem.7b00930
Affinity biochemical relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
468
Selectivity remarks
Screened at 10 µM, closest targets as % of contr.: CLK2 (25%), PIK3C2G (27%); Kd(mTOR) = 48 nM, Kd(PI3KC2b) = 40 nM (Kds by DiscoverX, PMID:28829592)
Selectivity Source Knowledge
https://doi.org/10.1021/acs.jmedchem.7b00930
Selectivity Number of Off-targets
0