Compound name
WNK463
Protein family
Protein Kinase
Target name
WNK2
Affinity biochemical (nM)
1
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000054b
SMILES
CC(C)(C)NC(=O)c1cncn1C1CCN(c2ccc(-c3nnc(C(F)(F)F)o3)cn2)CC1
InChIKey
HWSHOMMVLGBIDN-UHFFFAOYSA-N
NCBI gene ID
65268
UniProt ID
Q9Y3S1
Synonyms
NY-CO-43, KIAA1760
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Radiometric assay (incorporation of 33P from [γ-33P]ATP into myelin basic protein (MBP))
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/27595330/
Affinity biochemical relation
=
Selectivity platform
KinomeScan (Ambit, reporter ligand binding assay)
Selectivity platform number of targets
443
Selectivity remarks
Screened at 10 µM, closest targets as % control activity: HIPK2 (47%)
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/27595330/
Selectivity Number of Off-targets
0