Compound name
OTS964
Protein family
Protein Kinase
Target name
CDK11B
Affinity biochemical (nM)
40
Affinity on-target cellular (nM)
102
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000055a
SMILES
Cc1cc(O)c(-c2ccc([C@@H](C)CN(C)C)cc2)c2c1[nH]c(=O)c1sccc12
InChIKey
XCFRUAOZMVFDPQ-AWEZNQCLSA-N
NCBI gene ID
984
UniProt ID
P21127
Synonyms
#N/D
Mode of action
Inhibitor
Affinity biochemical definition
Kd
Affinity biochemical assay type
Binding assay
Affinity Biochemical Source Knowledge
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717492/
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET assay (CDK11/cyclin L2, HEK293T cells)
Affinity on-target cellular source knowledge
https://pubmed.ncbi.nlm.nih.gov/36104565/
Affinity on-target cellular relation
=
Selectivity platform
Kinase panel (Eurofins)
Selectivity platform number of targets
412
Selectivity remarks
Screened at 1 µM, closest targets as % of control: TYK2 (20%), EGFR(L861Q, 24%), EGFR(L858R, 27%), full screening data available as supplement information;
Screened at 2 µM against 60 kinases, HotSpot assay platform (Reaction Biology), closest targets as % inhibition: SRC (87.6%), FLT3 (72.1%), LYN (77.4%), https://www.science.org/doi/10.1126/scitranslmed.3010277?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed;
Screened at 2 µM against 60 kinases, HotSpot assay platform (Reaction Biology), closest targets as % inhibition: SRC (87.6%), FLT3 (72.1%), LYN (77.4%), https://www.science.org/doi/10.1126/scitranslmed.3010277?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed;
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/36104565/
Selectivity Number of Off-targets
0