Compound name
WNK-IN-11
Protein family
Protein Kinase
Target name
WNK1
Affinity biochemical (nM)
42
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000067b
SMILES
CNc1nc(-c2cc(C(=O)N3CCN(Cc4ccc(Cl)cc4)CC3)c(Cl)cn2)cs1
InChIKey
MVXAYIXYYOVALX-UHFFFAOYSA-N
NCBI gene ID
65125
UniProt ID
Q9H4A3
Synonyms
HSAN2, PPP1R167
Mode of action
Allosteric Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
HTRF assay
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/28771350/
Affinity biochemical relation
=
Selectivity platform
KinomeScan (Ambit)
Selectivity platform number of targets
440
Selectivity remarks
Screened at 10 µM, closest targets as % of control: BTK (1.4%), FER (6%), MAPK14 (11%), WNK1 (2.8%);
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/28771350/
Selectivity Number of Off-targets
2