Compound name
LXR-623
Protein family
NR
Target name
NR1H3
Affinity on-target cellular (nM)
7000
CG-Set
NR
Recommended Concentration
3 µM
Compound EUbOPEN ID
EUB0000082b
SMILES
FC(C=C1)=CC=C1C2=C3C(C(C(F)(F)F)=CC=C3)=NN2CC4=CC=C(F)C=C4Cl
InChIKey
KYWWJENKIMRJBI-UHFFFAOYSA-N
NCBI gene ID
10062
UniProt ID
Q13133
Synonyms
LXR-a, RLD-1, LXRa
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://doi.org/10.1021/jm800799q
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
fold-activation(NR1I2) = 2.24, fold-activation(NR2E1) = 1.84, inactive at 3 µM for NR1H4, UL48, RXRA, HNF4A, NR2C1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037
Selectivity Number of Off-targets
2