1. Chemogenomics
  2. Chemogenomic set
  3. EUB0000102c_BRDT

EUB0000102c_BRDT

Chemical structure of compound EUB0000102c
Compound name
I-BET151 (GSK1210151A)
Protein family
Bromodomain
Target name
BRDT
CG-Set
Epigenetic set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000102c
SMILES
COc1cc2c(cc1-c1c(C)noc1C)ncc1nc(O)n([C@H](C)c3ccccn3)c12
InChIKey
VUVUVNZRUGEAHB-CYBMUJFWSA-N
NCBI gene ID
676
UniProt ID
Q58F21
Synonyms
BRD6, CT9
Mode of action
Inhibitor
Selectivity platform
Bromodomain panel (DSF assays, literature)
Selectivity platform number of targets
26
Selectivity remarks
Screened at 100 µM in DSF assay, closest target: dTm(CEREBBP) = 1-3 K; Screened in CEREP panel against 50 GPCRs, ion channels and transporters at 10 µM, closest target as % inhibition: NK2 (48%)
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/21964340/