Compound name
ICG-001
Protein family
Apoptosis regulator
Target name
CTNNB1
Affinity on-target cellular (nM)
3000
CG-Set
Other targets
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000116c
SMILES
O=C1[C@H](Cc2ccc(O)cc2)N2C(=O)CCN(C(=O)NCc3ccccc3)[C@H]2CN1Cc1cccc2ccccc12
InChIKey
HQWTUOLCGKIECB-XZWHSSHBSA-N
NCBI gene ID
1499
UniProt ID
P35222
Synonyms
CTNNB, MRD19, EVR7
Mode of action
Inhibitor
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
TOPFLASH reporter assay (using SW480 colon carcinoma cells)
Affinity on-target cellular source knowledge
https://www.pnas.org/doi/10.1073/pnas.0404875101?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Affinity on-target cellular relation
=
Selectivity remarks
No inhibition of AP-1 and CRE (IC50 >100 µM, TOPFLASH reporter assay); no interaction with the beta-catenin transcriptional coactivator p300.
Selectivity Source Knowledge
https://www.pnas.org/doi/10.1073/pnas.0404875101?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed