Compound name
Barasertib-HQPA
Protein family
Protein Kinase
Target name
AURKB
Affinity biochemical (nM)
0.37
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000125b
SMILES
CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO
InChIKey
QYZOGCMHVIGURT-UHFFFAOYSA-N
NCBI gene ID
9212
UniProt ID
Q96GD4
Synonyms
Aik2, IPL1, AurB, AIM-1, ARK2, STK5, PPP1R48
Mode of action
Active inhibitor of prodrug AZD1152
Affinity biochemical definition
Ki
Affinity biochemical assay type
Enzymatic assay
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/17026809/
Affinity biochemical relation
=
Selectivity platform
Kinase panel (DSF assay)
Selectivity platform number of targets
100
Selectivity remarks
Screened at 20 µM, closest targets with dTm >3K: dTm(AURKB) = 13.8 K, dTm(STK6) = 9.08 K, dTm(FLT1) = 4.33 K;
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/17026809/