Compound name
Selumetinib
Protein family
Protein Kinase
Target name
MAP2K1
Affinity biochemical (nM)
99
Affinity on-target cellular (nM)
14
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000129b
SMILES
CN(C=N1)C2=C1C(F)=C(NC3=CC=C(Br)C=C3Cl)C(C(NOCCO)=O)=C2
InChIKey
CYOHGALHFOKKQC-UHFFFAOYSA-N
NCBI gene ID
5604
UniProt ID
Q02750
Synonyms
MEK1, MAPKK1
Mode of action
Inhibitor
Affinity biochemical definition
Kd
Affinity biochemical assay type
Competition binding assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1038/nbt.1990
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Inhibition of MEK1 human HeLa-Ma Tu matched pair cells
Affinity on-target cellular relation
=
Selectivity platform
Kinase panel, literature
Selectivity platform number of targets
442
Selectivity remarks
Kinases screened via competition binding assays: S(Kd < 300 nM) = 0.0026, S(Kd < 3µM) = 0.0052
Selectivity Source Knowledge
https://doi.org/10.1038/nbt.1990
Selectivity Number of Off-targets
0