Compound name
MK-2206 2HCl
Protein family
Protein Kinase
Target name
AKT2
Affinity biochemical (nM)
12
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000130bCl
SMILES
Cl.Cl.NC1(c2ccc(-c3nc4ccn5c(=O)[nH]nc5c4cc3-c3ccccc3)cc2)CCC1
InChIKey
HWUHTJIKQZZBRA-UHFFFAOYSA-N
NCBI gene ID
208
UniProt ID
P31751
Synonyms
PKBb
Mode of action
Allosteric inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzyme activity assay
Affinity Biochemical Source Knowledge
https://cancerres.aacrjournals.org/content/69/9_Supplement/DDT01-1
Affinity biochemical relation
=
Selectivity platform
Kinase panel, literature
Selectivity platform number of targets
250
Selectivity remarks
Screened at 1 µM, highly selective allosteric inhibitor
Selectivity Source Knowledge
https://cancerres.aacrjournals.org/content/69/9_Supplement/DDT01-1
Selectivity Number of Off-targets
0