Compound name
SR318
Protein family
Protein Kinase
Target name
MAPK11
Affinity biochemical (nM)
32
Affinity on-target cellular (nM)
10
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000132b
SMILES
Nc1c(C(=O)NCc2ccc(C(=O)NCCCC3CCCCC3)cc2)cnn1-c1ccccc1
InChIKey
HXNUFFCHRIWTRZ-UHFFFAOYSA-N
NCBI gene ID
5600
UniProt ID
Q15759
Synonyms
p38-2, p38Beta, SAPK2
Mode of action
Inhibitor
Negative control
SR321
Affinity biochemical definition
IC50
Affinity biochemical assay type
Radiometric activity assay (ProQinase)
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/acs.jmedchem.9b01227
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET assay (HEK293T cells)
Affinity on-target cellular relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
403
Selectivity remarks
Screened at 1 µM, closest targets in the screen: DDR1, DDR2, KIT, ZAK, RSK, MYLK4, but confirmed by NanoBRET as false positive (IC50s of 910-140000 nM)
Selectivity Source Knowledge
https://doi.org/10.1021/acs.jmedchem.9b01227
Selectivity Number of Off-targets
0