Compound name
SR318
Protein family
Protein Kinase
Target name
MAPK14
Affinity biochemical (nM)
5
Affinity on-target cellular (nM)
3.7
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000132b
SMILES
Nc1c(C(=O)NCc2ccc(C(=O)NCCCC3CCCCC3)cc2)cnn1-c1ccccc1
InChIKey
HXNUFFCHRIWTRZ-UHFFFAOYSA-N
NCBI gene ID
1432
UniProt ID
Q16539
Synonyms
PRKM14, p38, Mxi2, PRKM15
Mode of action
Inhibitor
Negative control
SR321
Affinity biochemical definition
IC50
Affinity biochemical assay type
Radiometric activity assay (ProQinase)
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/acs.jmedchem.9b01227
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET assay (HEK293T cells)
Affinity on-target cellular relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
403
Selectivity remarks
Screened at 1 µM, closest targets in the screen: DDR1, DDR2, KIT, ZAK, RSK, MYLK4, but confirmed by NanoBRET as false positive (IC50s of 910-140000 nM)
Selectivity Source Knowledge
https://doi.org/10.1021/acs.jmedchem.9b01227
Selectivity Number of Off-targets
0