Compound name
GDC-0879
Protein family
Protein Kinase
Target name
BRAF
Affinity biochemical (nM)
0.13
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000135b
SMILES
OCCn1cc(-c2ccc3c(c2)CCC3=NO)c(-c2ccncc2)n1
InChIKey
DEZZLWQELQORIU-UHFFFAOYSA-N
NCBI gene ID
673
UniProt ID
P15056
Synonyms
BRAF1
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Radiometric assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1016/j.bmcl.2008.07.002
Affinity biochemical relation
=
Selectivity platform
Kinase panel, literature
Selectivity platform number of targets
212
Selectivity remarks
Screened at 1 µM, closest target as % of contr.: RAF1 (8%)
Selectivity Source Knowledge
https://doi.org/10.1016/j.bmcl.2008.07.002
Selectivity Number of Off-targets
1