Compound name
LDC1267
Protein family
Protein Kinase
Target name
TYRO3
Affinity biochemical (nM)
8
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000147b
SMILES
CCOc1cn(-c2ccc(F)cc2C)nc1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1
InChIKey
ISPBCAXOSOLFME-UHFFFAOYSA-N
NCBI gene ID
7301
UniProt ID
Q06418
Synonyms
Dtk, Brt, Tif, Sky, Etk-2, Rek
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
HTRF assay
Affinity Biochemical Source Knowledge
https://doi.org/0.1038/nature12998
Affinity biochemical relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
465
Selectivity remarks
Screened at 1 µM, closest targets with <10% of contr.: ABL1, BLK, DDR1, FLT3, KIT, LCK, STK10, MAP2K5, MET, HIPK4, AURKB/C, FER, HCK, MST1R, CDK19, FRK, SRC, TIE1, CHEK2, MUSK, CDK8, CSF1R, EPHB6, PDGFRB, ROS1, NRTK1/3, MAP4K5, and mutants; Cellular selectivity (quantitative chemical proteomics, cell-based phosphorylation and proliferation assays in Hs578t cells), closest targets: Kd(cMET) = 13 nM,Kd(FER) = 107 nM, Kd(MAP2K5) = 124 nM, Kd(ABL1) = 154 nM, Kd(SRC) = 217 nM;
Selectivity Source Knowledge
https://doi.org/0.1038/nature12998
Selectivity Number of Off-targets
29