Compound name
GSK2334470
Protein family
Protein Kinase
Target name
PDPK1
Affinity biochemical (nM)
2.5
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000153b
SMILES
CNc1nc(-c2ccc3c(N)n[nH]c3c2)cc(N2C[C@@H](C(=O)NC3CCCCC3)CC[C@H]2C)n1
InChIKey
QLPHOXTXAKOFMU-WBVHZDCISA-N
NCBI gene ID
5170
UniProt ID
O15530
Synonyms
PDK1
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic inhibition assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/jm101527u
Affinity biochemical relation
=
Selectivity platform
Kinase panel (Millipore)
Selectivity platform number of targets
285
Selectivity remarks
Screened at 10 µM, closest targets as % of contr.: SGK2 (0%), PRKX (4%), RSK4 (12%), SGK (13%), RSK3 (14%), NUAK1 (16%), ROCK2 (17%); Screened against panel of 13 kinases (PDK, AKT1, ALK5, ASK1, AURA, AURB, EGFR, GSK3B, IKK1, PIK3CG, ROCK1, SYK, VEGFR2): IC50(ODK) = 2.5 nM, IC50(AURB) = 3162 nM, IC50(ROCK1) = 7943 nM, others >10 µM;
Selectivity Source Knowledge
https://doi.org/10.1021/jm101527u
Selectivity Number of Off-targets
7