Compound name
BI-1347
Protein family
Protein Kinase
Target name
CDK8
Affinity biochemical (nM)
1
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000162b
SMILES
CN(C)C(=O)Cn1cc(-c2ccc(-c3cncc4ccccc34)cc2)cn1
InChIKey
WULUGQONDYDNKY-UHFFFAOYSA-N
NCBI gene ID
1024
UniProt ID
P49336
Synonyms
K35
Mode of action
Inhibitor
Negative control
BI-1374
Affinity biochemical definition
IC50
Affinity biochemical assay type
Lantha screen (CDK8/cyclinC inhibition)
Affinity Biochemical Source Knowledge
https://opnme.com/molecules/cdk8-bi-1347
Affinity biochemical relation
=
Selectivity platform
Invitrogen® panel
Selectivity platform number of targets
369
Selectivity remarks
In-vitro potency of closest target: IC50(CDK11) = 1.7 nM
Selectivity Source Knowledge
https://opnme.com/molecules/cdk8-bi-1347#