Compound name
Bexarotene
Protein family
Nuclear Receptors
Target name
NR2B1
Affinity on-target cellular (nM)
30
CG-Set
Nuclear Receptor set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000181a
SMILES
C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C
InChIKey
NAVMQTYZDKMPEU-UHFFFAOYSA-N
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://doi.org/10.1021/jm00016a018
https://doi.org/10.1021/jm00044a014
Affinity on-target cellular relation
0
Selectivity platform
literature
Selectivity remarks
EC50 at 196 nM for NR1H3, EC50 at 434 nM for NR1H2
Selectivity Source Knowledge
https://doi.org/10.1016/j.bmcl.2017.01.066
Selectivity Number of Off-targets
2