Compound name
GW7647
Protein family
NR
Target name
PPARG
Affinity on-target cellular (nM)
1000
CG-Set
NR
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000185b
SMILES
CC(C)(C(=O)O)SC1=CC=C(C=C1)CCN(CCCCC2CCCCC2)C(=O)NC3CCCCC3
InChIKey
PKNYXWMTHFMHKD-UHFFFAOYSA-N
NCBI gene ID
5468
UniProt ID
P37231
Synonyms
PPARG1, PPARG2, NR1C3, PPARgamma
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://doi.org/10.1016/s0960-894x(01)00188-3
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
fold-activation(PPARD) = 19.05, inactive at 1 µM for UL48, RXRA, HNF4A, NR2C1, NR2E1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037
Selectivity Number of Off-targets
1