Compound name
A-366
Protein family
HMT
Target name
EHMT2/G9a@Methyltransferase
Affinity biochemical (nM)
3
CG-Set
Epigenetic set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000212b
SMILES
COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C21CCC1
InChIKey
BKCDJTRMYWSXMC-UHFFFAOYSA-N
NCBI gene ID
10919
UniProt ID
Q96KQ7
Synonyms
G9A, Em:AF134726.3, NG36/G9a, KMT1C
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Scintillation proximity assay (SPA)
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/ml400496h
https://www.thesgc.org/chemical-probes/A-366
Affinity biochemical relation
=
Selectivity platform
Methyltransferade panel, literature
Selectivity platform number of targets
21
Selectivity remarks
Selectivity on methyltransferases measured by scintillation proximity assay (SPA), selective <50 µM
Selectivity Source Knowledge
https://doi.org/10.1021/ml400496h
https://www.thesgc.org/chemical-probes/A-366
Selectivity Number of Off-targets
0