Compound name
BAY-6035
Protein family
HMT
Target name
SMYD3@Methyltransferase
Affinity biochemical (nM)
88
CG-Set
Epigenetic set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000221b
SMILES
C[C@H]1CC(=O)Nc2cc(C(=O)NCCC3CC3)ccc2N1C(=O)N1CC2CC2C1
InChIKey
CKFRXCBNKKOFGO-IGEOTXOUSA-N
NCBI gene ID
64754
UniProt ID
Q9H7B4
Synonyms
KMT3E
Mode of action
Peptide-competitive inhibitor
Negative control
BAY-444
Affinity biochemical definition
IC50
Affinity biochemical assay type
Scintillation proximity assay (SPA)
Affinity Biochemical Source Knowledge
https://www.thesgc.org/chemical-probes/BAY-6035
Affinity biochemical relation
=
Selectivity platform
Methyltransferase panel, literature
Selectivity platform number of targets
34
Selectivity remarks
Screened at 1 µM and 10 µM, highly selective for SMYD3 with no activity on other methyltransferases; Screened against 31 kinases in enzyme assays, closest target T-Fyn (HTRF assay) = 5.71 µM, others >20 µM;
Selectivity Source Knowledge
https://doi.org/10.1177/24725552211019409
Selectivity Number of Off-targets
0