Compound name
IOX2
Protein family
Hydroxylase
Target name
EGLN1
Affinity biochemical (nM)
22
CG-Set
Other targets set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000227d
SMILES
CC(CS(=O)(N[C@H]1CCC(N(C2=CC3=C(C(C)=CC(N3C)=O)C=C2)[C@@H]1C4=CC=C(C=C4)Cl)=O)=O)C
InChIKey
LVDRREOUMKACNJ-BKMJKUGQSA-N
NCBI gene ID
54583
UniProt ID
Q9GZT9
Synonyms
C1orf12, ECYT3, HALAH, HIF-PH2, HIFPH2, HPH-2, HPH2, PHD2, SM20, ZMYND6
Mode of action
Inhibitor
Negative control
No control available for probe
Affinity biochemical definition
IC50
Affinity biochemical assay type
AlphaScreen assay
Affinity Biochemical Source Knowledge
https://www.thesgc.org/chemical-probes/IOX2
Affinity biochemical relation
0
Selectivity platform
CEREP panel (receptors and ion channels)
Selectivity platform number of targets
55
Selectivity remarks
Screened at 10 µM, closest targets as % control binding: Cl-channel, GABA gated (70%), Adenosine A1 (82%); Selectivity against histone demethylases, in-vitro potency (AlphaScreen assay): IC50(KDM4A) = 100 µM, IC50(KDM4C) = 100 µM, IC50(KDM4E) >100 µM, IC50(KDM6B) >100 µM, IC50(KDM3A) >100 µM, IC50(KDM2A) = 52 µM, IC50(KDM5C) = 159 µM
Selectivity Source Knowledge
https://www.thesgc.org/chemical-probes/IOX2
Selectivity Number of Off-targets
0