Compound name
TH-257
Protein family
Protein Kinase
Target name
LIMK1
Affinity biochemical (nM)
84
Affinity on-target cellular (nM)
250
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000232b
SMILES
CCCCN(Cc1ccccc1)C(=O)c1ccc(S(=O)(=O)Nc2ccccc2)cc1
InChIKey
VNCIWNGCMAKKEO-UHFFFAOYSA-N
NCBI gene ID
3984
UniProt ID
P53667
Synonyms
LIMK
Mode of action
Allosteric inhibitor
Negative control
TH-263
Affinity biochemical definition
IC50
Affinity biochemical assay type
RapidFire MS assay
Affinity Biochemical Source Knowledge
https://www.thesgc.org/chemical-probes/TH-257
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET assay (HEK293T cells)
Affinity on-target cellular relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
448
Selectivity remarks
Screened at 1 µM, no significant activities below 50%
Selectivity Source Knowledge
https://www.thesgc.org/chemical-probes/TH-257
Selectivity Number of Off-targets
0