Compound name
TL4-12
Protein family
Protein Kinase
Target name
MAP4K2
Affinity biochemical (nM)
37
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000238b
SMILES
CNc1cc(Oc2cc(C(=O)Nc3cc(N4CCN(C)CC4)cc(C(F)(F)F)c3)ccc2C)ncn1
InChIKey
HXKJJIMUMNPQQY-UHFFFAOYSA-N
NCBI gene ID
5871
UniProt ID
Q12851
Synonyms
GCK, BL44
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic inhibition assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/jm500480k
Affinity biochemical relation
=
Selectivity platform
KiNativ profiling (A375 live cells treatment assays)
Selectivity platform number of targets
220
Selectivity remarks
Screened at 1 µM, closest targets as % inhibition: ABL1(49%) and ABL2 (49%);
Selectivity Source Knowledge
https://doi.org/10.1021/jm500480k
Selectivity Number of Off-targets
0