Compound name
A-1155463
Protein family
Apoptosis regulator
Target name
BCL2L1
Affinity biochemical (nM)
0.55
CG-Set
Other targets
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000262b
SMILES
CN(C)CC#Cc1ccc(OCCCc2sc(N3CCc4cccc(C(=O)Nc5nc6ccccc6s5)c4C3)nc2C(=O)O)c(F)c1
InChIKey
SOYCFODXNRVBTI-UHFFFAOYSA-N
NCBI gene ID
598
UniProt ID
Q07817
Synonyms
BCL2L1, BCL2L, BCLX
Mode of action
Inhibitor
Negative control
A-1107969
Affinity biochemical definition
IC50
Affinity biochemical assay type
TR-FRET assay
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/A-1155463
Affinity biochemical relation
=
Selectivity platform
CEREP panel (Eurofins)
Selectivity platform number of targets
71
Selectivity remarks
Screened at 10 µM (binding assay), closest targets as % inhibition: PPARG (99.1%), CCKAR (98.9%), UTS2R (94.9%), OPRD1 (77.9%), MAOA (74.5%), ADORA3 (71.6%), HRH1 (69.2%), PTGS2 (62.2%); Screened against 468 kinase targets (KinomeScan DiscoverX) at 1 µM, closest targets as % contr.: AURKC (9%), MARK3 (38%); Screened against 45 GPCR targets (PDSP screen) at 10 µM, closest targets: Ki(SIGMAR1) = 136.4 nM, Ki(GABA/PBR) = 793.96 nM, Ki(TMEM97) = 806.12 nM, Ki(HTR3A) = 1142.6 nM, Ki(HRH3) = 1806.76 nM, Ki(OPRD1) = 2118.36 nM; Screened in Eurofins-Cerep panel against 7 targets at 10 µM (enzymes and uptake assays): clean profile;
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/A-1155463
Selectivity Number of Off-targets
0