Compound name
BI01383298
Protein family
SLC
Target name
SLC13A5
Affinity on-target cellular (nM)
24
CG-Set
Ion Channel
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000282b
SMILES
O=C(NCc1ccc(F)cc1)C1CCN(S(=O)(=O)c2cc(Cl)cc(Cl)c2)CC1
InChIKey
VUOYAALVGSMUHC-UHFFFAOYSA-N
NCBI gene ID
284111
UniProt ID
Q86YT5
Synonyms
EIEE25 INDY NACT mIndy
Mode of action
Inhibitor
Negative control
BI01372674
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Citrate uptake inhibition assay (HepG2 cells expressing endogenous SLC13A5)
Affinity on-target cellular relation
=
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against a panel of ion channels, GPCRs, hydrolases and other enzymes, closest target as % of contr.: NA+/SITE2/R (48%, voltage-gated ion channel) 1000-fold selective over closest family members: human SLC13A2 and SLC13A3 that share physiological substrates citrate and succinate
Selectivity Source Knowledge
https://opnme.com/molecules/slc13a5-bi01383298#
Selectivity Number of Off-targets
0