Compound name
BI-9627
Protein family
SLC
Target name
SLC9A1
Affinity biochemical (nM)
6
CG-Set
Ion Channel
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000295b
SMILES
CC(=O)N1CCC(c2ccc(C(=O)NC(=N)N)cc2C(F)(F)F)CC1
InChIKey
QMHRLXNEGYTSRV-UHFFFAOYSA-N
NCBI gene ID
6548
UniProt ID
P19634
Synonyms
APNH LIKNS NHE-1 NHE1 PPP1R143
Mode of action
Antagonist
Affinity biochemical definition
IC50
Affinity biochemical assay type
pHi change assay
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!orderview/BI-9627
Affinity biochemical relation
=
Selectivity remarks
Solute carrier family 9 isoform selectivity: > 30-fold selective versus SLC9A2 (IC50 = 231 nM) and >1000-fold versus SLC9A3 (IC50 >16 µM); Screened against 45 GPCR targets (PDSP screen) at 10 µM, closest target: Ki(DAT) = 1523 nM; Selective in KinomeScan (DiscoverX) against 468 targets at 1 µM; Screened in Eurofins-Panlabs panel (68 targets), closest target M2 (67 % inhibition at 10 µM)
Selectivity Source Knowledge
https://pubs.acs.org/doi/10.1021/jm300601d
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BI-9627