Compound name
ERKi
Protein family
Protein Kinase
Target name
MAPK1
Affinity biochemical (nM)
4.8
Affinity on-target cellular (nM)
850
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000298b
SMILES
C[C@@H](NC(=O)Nc1cc2[nH]ncc2c(CO)n1)c1ccccc1
InChIKey
RAXZSEGXMBWYQK-SNVBAGLBSA-N
NCBI gene ID
5594
UniProt ID
P28482
Synonyms
ERK, ERK2, p41mapk, MAPK2
Mode of action
Inhibitor
Negative control
ERKi-NC
Affinity biochemical definition
Kd
Affinity biochemical assay type
KdELECT (DiscoverX)
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/ERKi
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET assay (HEK293T cells)
Affinity on-target cellular relation
=
Selectivity platform
ScanMAX (DiscoverX)
Selectivity platform number of targets
486
Selectivity remarks
Screened at 0.1 µM, closest targets: Kd(LATS2) = 55 nM, Kd(MAPK15) = 30 nM, Kd(TGFBR2) = 54 nM, Kd(ROCK2) = 82 nM, Kd(ULK1) = 140 nM
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/ERKi
Selectivity Number of Off-targets
10