Compound name
(R)-9s
Protein family
GPCR
Target name
ADRA1D
Affinity biochemical (nM)
1.6
CG-Set
GPCR set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000300bCl
SMILES
C[C@@H](c1cccc(CN)c1)n1cc(Cl)cc(C(N)=O)c1=N.Cl
InChIKey
PIRKVXKOMRREFI-FVGYRXGTSA-N
NCBI gene ID
146
UniProt ID
P25100
Synonyms
ADRA1R, ADRA1A, ADRA1
Mode of action
Antagonist
Negative control
(S)-9s
Affinity biochemical definition
Ki
Affinity biochemical assay type
Binding assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/acs.jmedchem.5b01528
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/(R)-9s
Affinity biochemical relation
=
Selectivity platform
GPCR screen (PDSP)
Selectivity platform number of targets
45
Selectivity remarks
Screened at 10 µM, closest targets as % inhibition: ADRA1A (84%), ADRA2B (80%); In vitro follow up: Ki(ADRA1A) >2.7 µM (> 1700 fold), Ki(ADRA1B) >1.2 µM (>750 fold); Screened against 468 kinases (KinomeScan, DiscoverX) at 1 µM, closest targets as % contr.: MAPK6 (0%), TYRO3 (33%);
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/(R)-9s
Selectivity Number of Off-targets
0