Compound name
BAY-707
Protein family
Nudix hydrolase family
Target name
NUDT1
Affinity biochemical (nM)
2.3
Affinity on-target cellular (nM)
7.6
CG-Set
Other targets
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000302b
SMILES
CCNC(=O)c1cc2c(N3CCOC[C@H]3C)ccnc2[nH]1
InChIKey
RPMGXDCRCWWCRY-SNVBAGLBSA-N
NCBI gene ID
4521
UniProt ID
P36639
Mode of action
Inhibitor
Negative control
BAY-604
Affinity biochemical definition
IC50
Affinity biochemical assay type
PPiLight Biochemical Assay (full-length human NUDT1)
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/acschembio.7b00370
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BAY-707
Affinity biochemical relation
=
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
CETSA (cellular thermal shift assay in K562 cells)
Affinity on-target cellular relation
=
Selectivity remarks
Selective across the Nudix family when tested in Tm shift assay; Screened against 45 GPCR targets (PDSP screen) at 10 µM, closest target: Ki(GABAA/BZP) = 1527 nM; Screened against 30 kinases at 40 µM (Bayer in-house kinase panel), all targets IC50 >8 µM (PMID: 28679043)
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BAY-707