Compound name
BI-1950
Protein family
Integrin
Target name
ITGAL
Affinity biochemical (nM)
9
CG-Set
Ion Channel
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000310b
SMILES
C[C@H](NC(=O)c1cnc2n1[C@](C)(Cc1ccc(C#N)cc1)C(=O)N2c1cc(Cl)c(F)c(Cl)c1)C(=O)NC1(c2ccccn2)CC1
InChIKey
JZTTUZXIQIRVAB-FZEVHQGJSA-N
NCBI gene ID
3683
UniProt ID
P20701
Synonyms
ITGAL, CD11A
Mode of action
Inhibitor
Negative control
BI-9446
Affinity biochemical definition
Kd
Affinity biochemical assay type
ITGAL binding assay (inhibition of LFA-1 binding to ICAM-1)
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BI-1950
Affinity biochemical relation
=
Selectivity platform
Eurofins Panlabs panel
Selectivity platform number of targets
47
Selectivity remarks
Screened against 47 receptors, ion channel and other enzymes at 10 µM, closest target as % inhibition: CACNA1C (72%), >1000 fold selective against closely related ITGB2 and ITGB1; Screened against 468 kinases (KinomeScan DiscoverX) at 1 µM, closest targets as % of contr.: STK39 (24%), EIF2AK2 (34%), STK38L (49%); Screened against 45 GPCR targets (PDSP screen) at 10 µM, closest target: TMEM97 (26%);
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BI-1950
Selectivity Number of Off-targets
0