Compound name
BAY-3827
Protein family
Protein Kinase
Target name
RPS6KA1
Affinity biochemical (nM)
9.1
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000311b
SMILES
CCc1ccccc1C(=O)Nc1n[nH]c2c(C)c(F)c(C3C(C#N)=C(C)N(C)C(C)=C3C#N)cc12
InChIKey
OZFFKOSQNBBYCA-UHFFFAOYSA-N
NCBI gene ID
6196
UniProt ID
Q15349
Synonyms
RSK3, HU-2
Mode of action
Inhibitor
Negative control
BAY-974
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic inhibition assay
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/BAY-3827
Affinity biochemical relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
468
Selectivity remarks
Screened at 1 µM, in-vitro potencies of closest targets: Kd(RPS6KA3) = 52 nM, Kd(RPS6KA2) = 24 nM, Kd(RPS6KA6) = 36 nM, Kd(FLT3) = 124 nM, Kd(RPS6KA5) = 43 nM, Kd(MST3) = 94 nM
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/BAY-3827