Compound name
BI-653048
Protein family
Nuclear-receptor
Target name
NR3C1
Affinity biochemical (nM)
55
CG-Set
NR set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000314b
SMILES
CCS(=O)(=O)c1cc2cc(C[C@](O)(CC(C)(C)c3ccc(F)cc3C(N)=O)C(F)(F)F)[nH]c2cn1
InChIKey
AUIFRJWXYUNPPV-QFIPXVFZSA-N
NCBI gene ID
2908
UniProt ID
P04150
Synonyms
GR
Mode of action
Agonist
Negative control
BI-3047
Affinity biochemical definition
IC50
Affinity biochemical assay type
Fluorescence polarization assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/ml500387y
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BI%20653048
Affinity biochemical relation
=
Selectivity remarks
> 100 fold selective against related nuclear receptors (PGR, NR3C2, ESR1, AR); Screened against 45 GPCR targets (PDSP screen) at 10 µM, closest target as % of contr: DRD5 (34%); Screened against 49 targets (Eurofins-Panlabs panel at Boehringer Ingelheim) at 10 µM: clean profile; Screened against 468 kinases (KinomeScan DiscoverX) at 1 µM, closest targets as % of contr.: LATS2(40%)
Selectivity Source Knowledge
https://doi.org/10.1021/ml500387y
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BI%20653048