Compound name
TP-024
Protein family
GPCR
Target name
GPR52
Affinity on-target cellular (nM)
93
CG-Set
GPCR set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000317b
SMILES
Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O
InChIKey
TYXSIXOYTBHZFA-UHFFFAOYSA-N
NCBI gene ID
9293
UniProt ID
Q9Y2T5
Mode of action
Agonist
Negative control
TP-024n
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/TP-024
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
Cell-based cAMP assay
Affinity on-target cellular relation
=
Selectivity platform
GPCR screen (PDSP)
Selectivity platform number of targets
45
Selectivity remarks
Screened at 10 µM, closest target as % of inhibition: HTR7 (21%); Screened against 468 kinases (KinomeScan DiscoverX) at 1 µM, closest target as % of contr.: STK38L (49%); Clean in Diversity panel screen (by Ricerca) against>100 targets, at 10 µM
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/TP-024
Selectivity Number of Off-targets
0