Compound name
BI-1675
Protein family
Protease
Target name
HCV:NS3
Affinity biochemical (nM)
4870
CG-Set
Protease set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000319b
SMILES
O=C(N[C@H]1CCCCC/C=C\C2C[C@@]2(C(=O)O)NC(=O)[C@@H]2C[C@@H](Oc3ccncc3)CN2C1=O)OC1CCCC1
InChIKey
WJXNVDYYZYLOAF-GILVJNHZSA-N
UniProt ID
P26662
Mode of action
Negative control for BI-1230
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic assay (using a NS3-NS4A heterodimer and a fluorogenic substrate)
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BI-1230
Affinity biochemical relation
0
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
468
Selectivity remarks
Screened at 1 µM, closest targets as % of contr.: MYO3B (38%), MATK(41%), DYRK1B (46%); Screened at 10 µM against 45 GPCRs (PDSP screen), closest targets as % of inhibition: ADRA1A(25.68%), HRH1(23.9%), TMEM97(18.5%)
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/BI-1230
Selectivity Number of Off-targets
0