Compound name
WM-1119
Protein family
HAT
Target name
MYST3@Acetyltransferase
Affinity biochemical (nM)
2
CG-Set
Epigenetic set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000329a
SMILES
FC1=CC=CC=C1S(NNC(C2=CC(F)=CC(C3=NC=CC=C3)=C2)=O)(=O)=O
InChIKey
QLXULUNLCRKWRD-UHFFFAOYSA-N
NCBI gene ID
7994
UniProt ID
Q92794
Synonyms
MOZ, ZC2HC6A
Mode of action
Inhibitor
Negative control
WM-2474
Affinity biochemical definition
Kd
Affinity biochemical assay type
Surface plasmon resonance (SPR)
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/acs.jmedchem.9b02071
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/WM-1119
Affinity biochemical relation
=
Selectivity platform
HAT panel, literature
Selectivity platform number of targets
6
Selectivity remarks
> 200-fold selective on all other HATs tested; No significant activity on 166 targets at 10 µM (kinases, GPCRs, HDACs, phosphatases etc.), no target was affected by more than 50%, closest hits in the GPCR scan: Ki(DRD2) = 397.52 nM, GABAA/BZP (75.65 % inhibition)
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/WM-1119
Selectivity Number of Off-targets
0