Compound name
WM-1119
Protein family
HAT
Target name
MYST4@Acetyltransferase
Affinity on-target cellular (nM)
6.3
CG-Set
Epigenetic set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000329a
SMILES
FC1=CC=CC=C1S(NNC(C2=CC(F)=CC(C3=NC=CC=C3)=C2)=O)(=O)=O
InChIKey
QLXULUNLCRKWRD-UHFFFAOYSA-N
NCBI gene ID
23522
UniProt ID
Q8WYB5
Synonyms
querkopf, qkf, Morf, MOZ2, ZC2HC6B
Mode of action
Inhibitor
Negative control
WM-2474
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
HAT binding assay
Affinity on-target cellular relation
=
Selectivity platform
HAT panel, literature
Selectivity platform number of targets
6
Selectivity remarks
> 200-fold selective on all other HATs tested; No significant activity on 166 targets at 10 ?M (Kinases, GPCRs, HDACs, phosphatases etc.), no target was affected by more than 50%, closest hits in the GPCR scan: Ki(DRD2) = 397.52 nM, GABAA/BZP (75.65 % inhibition)
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/WM-1119
Selectivity Number of Off-targets
0