Compound name
KISS1-305
Protein family
GPCR
Target name
KISS1R
Affinity biochemical (nM)
0.089
CG-Set
GPCR set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000349a
SMILES
CC(C[C@H](NC(NNC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@H](N)CC1=CC=C(O)C=C1)=O)CC2=CC=NC=C2)=O)CC(N)=O)=O)CO)=O)CC3=CC=CC=C3)=O)=O)C(N[C@H](C(N[C@H](C(N)=O)CC4=CC=CC=C4)=O)CCCNC(NC)=N)=O)C
InChIKey
YSVWFFNZZGLLAI-XNTOLAJGSA-N
NCBI gene ID
84634
UniProt ID
Q969F8
Synonyms
HOT7T175, AXOR12
Mode of action
Agonist
Negative control
KISS1-543
Affinity biochemical definition
Ki
Affinity biochemical assay type
Binding assay (used membrane fraction of human KISS1R-expressing cells)
Affinity Biochemical Source Knowledge
http://pubs.acs.org/doi/10.1021/jm401056w
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/KISS1-305
Affinity biochemical relation
=
Selectivity platform
GPCR screen (PDSP)
Selectivity platform number of targets
45
Selectivity remarks
Screened at 1 µM, closest target: Ki(OPRD1) = 47.5 nM; Potency against NPFFR2 (GPR74) and NPFFR1 (GPR147) >30 fold;
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/KISS1-305
Selectivity Number of Off-targets
1