Compound name
(R)-ZINC 3573
Protein family
GPCR
Target name
MRGPRX2
Affinity on-target cellular (nM)
740
CG-Set
GPCR set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000353a
SMILES
CN(C)[C@@H]1CCN(C1)c1cc(c2ccccc2)nc2ccnn12
InChIKey
XKBSPAZCFAIBJL-OAHLLOKOSA-N
NCBI gene ID
117194
UniProt ID
Q96LB1
Synonyms
MRGX2
Mode of action
Agonist
Negative control
(S)-ZINC 3573
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
PRESTO-Tango concentration response assay (by the NIMH-PDSP)
Affinity on-target cellular relation
=
Selectivity platform
PRESTO-Tango GPCRome screening
Selectivity platform number of targets
315
Selectivity remarks
Closest targets: Ki(DRD2) = 369.37 nM, Ki(TMEM97) = 489.44 nM, Ki(HTR6) = 748.23 nM; Screened against 45 GPCR targets (PDSD screen) at 10 µM, closest targets: Ki(D2) = 369.37 nM, Ki(5-HT6)= 748.23 nM, Ki(Sigma2) = 489.44 nM, Ki(DAT) = 1109 nM; Screened against 468 kinases (KINOMEscan DiscoverX) at 10 µM, closest targets: Kd(BTK) = 27 µM, Kd(MAPK8) = 19 µM, Kd(MAPK10) >30 µM, PMID: 28288109;
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/(R)-ZINC-3573
Selectivity Number of Off-targets
0