Compound name
Ogerin
Protein family
GPCR
Target name
GPR68
Affinity on-target cellular (nM)
148
CG-Set
GPCR set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000354a
SMILES
OCC1=CC=CC=C1C2=NC(N)=NC(NCC3=CC=CC=C3)=N2
InChIKey
MDGIEDNDSFMSLP-UHFFFAOYSA-N
NCBI gene ID
8111
UniProt ID
Q15743
Synonyms
OGR1
Mode of action
Allosteric modulator
Negative control
ZINC32547799
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
FLIPR-TETRA assay
Affinity on-target cellular relation
=
Selectivity platform
GPCR screen (PDSP)
Selectivity platform number of targets
45
Selectivity remarks
Highly selective in GPCR screen at 10 µM, clostest target: Ki(5-HT1A) = 849.9 nM
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/Ogerin
https://doi.org/10.1038/nature15699
Selectivity Number of Off-targets
0