Compound name
MONTELUKAST
Protein family
GPCR
Target name
CYSLTR1
Affinity biochemical (nM)
2.29
Affinity on-target cellular (nM)
72.44
Compound EUbOPEN ID
EUB0000423aNa
SMILES
CC(C)(O)C(C=CC=C1)=C1CC[C@@H](SCC2(CC2)CC([O-])=O)C3=CC(/C=C/C4=NC5=CC(Cl)=CC=C5C=C4)=CC=C3.[Na+]
InChIKey
LBFBRXGCXUHRJY-HKHDRNBDSA-M
NCBI gene ID
10800
UniProt ID
Q9Y271
Synonyms
CysLT1, CysLT(1), CYSLT1R
Mode of action
Antagonist
Affinity biochemical definition
IC50
Affinity biochemical assay type
Antagonist activity at human CysLT1
Affinity Biochemical Source Knowledge
26200813
Affinity biochemical relation
=
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge
Affinity on-target cellular relation
=