Compound name
SB-269970
Protein family
GPCR
Target name
HTR7
Affinity biochemical (nM)
1.55
Affinity on-target cellular (nM)
0.91
Compound EUbOPEN ID
EUB0000426aCl
SMILES
[H]Cl.CC1CCN(CC[C@H]2CCCN2S(=O)(=O)C2=CC=CC(O)=C2)CC1
InChIKey
XQCJOYZLWFNDIO-PKLMIRHRSA-N
NCBI gene ID
3363
UniProt ID
P34969
Synonyms
5-HT7
Mode of action
Antagonist
Affinity biochemical definition
Ki
Affinity biochemical assay type
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
Affinity Biochemical Source Knowledge
12392747
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
Affinity on-target cellular relation
=