Compound name
CINACALCET
Protein family
GPCR
Target name
CASR
Affinity biochemical (nM)
39.81
Affinity on-target cellular (nM)
177.83
CG-Set
Not included in the set
Compound EUbOPEN ID
EUB0000437aCl
SMILES
[H]Cl.C[C@@H](NCCCC1=CC=CC(=C1)C(F)(F)F)C1=CC=CC2=CC=CC=C12
InChIKey
QANQWUQOEJZMLL-PKLMIRHRSA-N
NCBI gene ID
846
UniProt ID
P41180
Synonyms
FHH, NSHPT, GPRC2A
Mode of action
Positive allosteric modulator
Affinity biochemical definition
EC50
Affinity biochemical assay type
Positive allosteric modulation of calcium sensing receptor by cell based assay
Affinity Biochemical Source Knowledge
20727747
Affinity biochemical relation
=
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
Agonist activity at human CaSR expressed in CHO cells assessed as increase in intracellular calcium mobilization after 1 hr by Fura-2 dye-based fluorescence assay
Affinity on-target cellular relation
=