Compound name
BINA
Protein family
GPCR
Target name
GRM2
Affinity biochemical (nM)
93.33
Affinity on-target cellular (nM)
27.54
Compound EUbOPEN ID
EUB0000454a
SMILES
CC1=C(C)C(OCC2=CC(=CC=C2)C2=CC=C(C=C2)C(O)=O)=CC2=C1C(=O)C(C2)C1CCCC1
InChIKey
KMKBEESNZAPKMP-UHFFFAOYSA-N
NCBI gene ID
2912
UniProt ID
Q14416
Synonyms
GPRC1B, mGlu2, MGLUR2
Mode of action
Positive allosteric modulator
Affinity biochemical definition
Kd
Affinity biochemical assay type
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay
Affinity Biochemical Source Knowledge
28704052
Affinity biochemical relation
=
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
Allosteric modulation of human mGluR2 expressed in CHO cells by [35S]GTPgammaS binding assay
Affinity on-target cellular relation
=